SGO2 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SGO2

Shugoshin 2 isoform X1. (1369 aa)

Predicted Functional Partners:

PLK1

0.904

NUDC

0.861

CDC20

0.858

ESPL1

0.821

SGO1

0.811

REC8

0.810

STAG3

0.700

BUB1B

0.679

MAD2L1

0.649

STAG2

0.638

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUB1B	CDC20	ENSSSCP00000022619	ENSSSCP00000004268	BUB1 N-terminal domain-containing protein.	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	0.995
BUB1B	ESPL1	ENSSSCP00000022619	ENSSSCP00000000280	BUB1 N-terminal domain-containing protein.	Extra spindle pole bodies like 1, separase.	0.976
BUB1B	MAD2L1	ENSSSCP00000022619	ENSSSCP00000031508	BUB1 N-terminal domain-containing protein.	Mitotic arrest deficient 2 like 1.	0.999
BUB1B	NUDC	ENSSSCP00000022619	ENSSSCP00000052911	BUB1 N-terminal domain-containing protein.	CS domain-containing protein.	0.599
BUB1B	PLK1	ENSSSCP00000022619	ENSSSCP00000023889	BUB1 N-terminal domain-containing protein.	Serine/threonine-protein kinase PLK.	0.978
BUB1B	SGO1	ENSSSCP00000022619	ENSSSCP00000011956	BUB1 N-terminal domain-containing protein.	Shugoshin 1.	0.919
BUB1B	SGO2	ENSSSCP00000022619	ENSSSCP00000017048	BUB1 N-terminal domain-containing protein.	Shugoshin 2 isoform X1.	0.679
CDC20	BUB1B	ENSSSCP00000004268	ENSSSCP00000022619	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	BUB1 N-terminal domain-containing protein.	0.995
CDC20	ESPL1	ENSSSCP00000004268	ENSSSCP00000000280	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	Extra spindle pole bodies like 1, separase.	0.988
CDC20	MAD2L1	ENSSSCP00000004268	ENSSSCP00000031508	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	Mitotic arrest deficient 2 like 1.	0.992
CDC20	NUDC	ENSSSCP00000004268	ENSSSCP00000052911	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	CS domain-containing protein.	0.811
CDC20	PLK1	ENSSSCP00000004268	ENSSSCP00000023889	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	Serine/threonine-protein kinase PLK.	0.998
CDC20	SGO1	ENSSSCP00000004268	ENSSSCP00000011956	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	Shugoshin 1.	0.943
CDC20	SGO2	ENSSSCP00000004268	ENSSSCP00000017048	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	Shugoshin 2 isoform X1.	0.858
ESPL1	BUB1B	ENSSSCP00000000280	ENSSSCP00000022619	Extra spindle pole bodies like 1, separase.	BUB1 N-terminal domain-containing protein.	0.976
ESPL1	CDC20	ENSSSCP00000000280	ENSSSCP00000004268	Extra spindle pole bodies like 1, separase.	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	0.988
ESPL1	MAD2L1	ENSSSCP00000000280	ENSSSCP00000031508	Extra spindle pole bodies like 1, separase.	Mitotic arrest deficient 2 like 1.	0.823
ESPL1	NUDC	ENSSSCP00000000280	ENSSSCP00000052911	Extra spindle pole bodies like 1, separase.	CS domain-containing protein.	0.537
ESPL1	PLK1	ENSSSCP00000000280	ENSSSCP00000023889	Extra spindle pole bodies like 1, separase.	Serine/threonine-protein kinase PLK.	0.993
ESPL1	REC8	ENSSSCP00000000280	ENSSSCP00000002187	Extra spindle pole bodies like 1, separase.	Meiotic recombination protein REC8 homolog.	0.981