node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | RUVBL1 | ENSSSCP00000009984 | ENSSSCP00000019846 | Cyclin-A1 isoform X1; Belongs to the cyclin family. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.512 |
CCNA1 | USP37 | ENSSSCP00000009984 | ENSSSCP00000017157 | Cyclin-A1 isoform X1; Belongs to the cyclin family. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.631 |
CLUAP1 | CRYBA2 | ENSSSCP00000041705 | ENSSSCP00000050236 | Clusterin associated protein 1. | Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. | 0.847 |
CLUAP1 | MAK16 | ENSSSCP00000041705 | ENSSSCP00000047933 | Clusterin associated protein 1. | Protein MAK16 homolog; Belongs to the MAK16 family. | 0.868 |
CLUAP1 | USP37 | ENSSSCP00000041705 | ENSSSCP00000017157 | Clusterin associated protein 1. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.778 |
CLUAP1 | VIL1 | ENSSSCP00000041705 | ENSSSCP00000017159 | Clusterin associated protein 1. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.544 |
CRYBA2 | CLUAP1 | ENSSSCP00000050236 | ENSSSCP00000041705 | Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. | Clusterin associated protein 1. | 0.847 |
CRYBA2 | MAK16 | ENSSSCP00000050236 | ENSSSCP00000047933 | Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. | Protein MAK16 homolog; Belongs to the MAK16 family. | 0.849 |
CRYBA2 | TNS1 | ENSSSCP00000050236 | ENSSSCP00000066244 | Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. | Tensin 1. | 0.611 |
CRYBA2 | USP37 | ENSSSCP00000050236 | ENSSSCP00000017157 | Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.754 |
CRYBA2 | VIL1 | ENSSSCP00000050236 | ENSSSCP00000017159 | Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.459 |
MAK16 | CLUAP1 | ENSSSCP00000047933 | ENSSSCP00000041705 | Protein MAK16 homolog; Belongs to the MAK16 family. | Clusterin associated protein 1. | 0.868 |
MAK16 | CRYBA2 | ENSSSCP00000047933 | ENSSSCP00000050236 | Protein MAK16 homolog; Belongs to the MAK16 family. | Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. | 0.849 |
MAK16 | TNS1 | ENSSSCP00000047933 | ENSSSCP00000066244 | Protein MAK16 homolog; Belongs to the MAK16 family. | Tensin 1. | 0.436 |
MAK16 | USP37 | ENSSSCP00000047933 | ENSSSCP00000017157 | Protein MAK16 homolog; Belongs to the MAK16 family. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.779 |
MAK16 | VIL1 | ENSSSCP00000047933 | ENSSSCP00000017159 | Protein MAK16 homolog; Belongs to the MAK16 family. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.547 |
MED13 | USP37 | ENSSSCP00000018726 | ENSSSCP00000017157 | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.639 |
RUVBL1 | CCNA1 | ENSSSCP00000019846 | ENSSSCP00000009984 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | Cyclin-A1 isoform X1; Belongs to the cyclin family. | 0.512 |
RUVBL1 | USP37 | ENSSSCP00000019846 | ENSSSCP00000017157 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.800 |
TNS1 | CRYBA2 | ENSSSCP00000066244 | ENSSSCP00000050236 | Tensin 1. | Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. | 0.611 |