RIF1 protein (Sus scrofa) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

RIF1

Replication timing regulatory factor 1. (2466 aa)

Predicted Functional Partners:

HEATR1

0.878

PAXIP1

0.854

ATM

0.834

SBNO1

0.834

BDP1

0.808

MSL3

0.786

PIAS4

0.752

SEC31A

0.742

TBL1XR1

0.731

TP53BP1

0.727

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	PAXIP1	ENSSSCP00000015931	ENSSSCP00000036427	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	PAX interacting protein 1.	0.875
ATM	PIAS4	ENSSSCP00000015931	ENSSSCP00000041262	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	Protein inhibitor of activated STAT 4.	0.723
ATM	RIF1	ENSSSCP00000015931	ENSSSCP00000017370	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	Replication timing regulatory factor 1.	0.834
ATM	TP53BP1	ENSSSCP00000015931	ENSSSCP00000037159	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	Tumor protein p53 binding protein 1.	0.963
BDP1	RIF1	ENSSSCP00000017977	ENSSSCP00000017370	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	Replication timing regulatory factor 1.	0.808
BDP1	SBNO1	ENSSSCP00000017977	ENSSSCP00000033831	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	Protein strawberry notch homolog 1 isoform X1.	0.413
HEATR1	RIF1	ENSSSCP00000010819	ENSSSCP00000017370	HEAT repeat containing 1.	Replication timing regulatory factor 1.	0.878
MSL3	RIF1	ENSSSCP00000061370	ENSSSCP00000017370	MSL complex subunit 3.	Replication timing regulatory factor 1.	0.786
MSL3	SEC31A	ENSSSCP00000061370	ENSSSCP00000067869	MSL complex subunit 3.	SEC31 homolog A, COPII coat complex component.	0.749
PAXIP1	ATM	ENSSSCP00000036427	ENSSSCP00000015931	PAX interacting protein 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	0.875
PAXIP1	PIAS4	ENSSSCP00000036427	ENSSSCP00000041262	PAX interacting protein 1.	Protein inhibitor of activated STAT 4.	0.573
PAXIP1	RIF1	ENSSSCP00000036427	ENSSSCP00000017370	PAX interacting protein 1.	Replication timing regulatory factor 1.	0.854
PAXIP1	TP53BP1	ENSSSCP00000036427	ENSSSCP00000037159	PAX interacting protein 1.	Tumor protein p53 binding protein 1.	0.913
PIAS4	ATM	ENSSSCP00000041262	ENSSSCP00000015931	Protein inhibitor of activated STAT 4.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	0.723
PIAS4	PAXIP1	ENSSSCP00000041262	ENSSSCP00000036427	Protein inhibitor of activated STAT 4.	PAX interacting protein 1.	0.573
PIAS4	RIF1	ENSSSCP00000041262	ENSSSCP00000017370	Protein inhibitor of activated STAT 4.	Replication timing regulatory factor 1.	0.752
PIAS4	TP53BP1	ENSSSCP00000041262	ENSSSCP00000037159	Protein inhibitor of activated STAT 4.	Tumor protein p53 binding protein 1.	0.636
RIF1	ATM	ENSSSCP00000017370	ENSSSCP00000015931	Replication timing regulatory factor 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	0.834
RIF1	BDP1	ENSSSCP00000017370	ENSSSCP00000017977	Replication timing regulatory factor 1.	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	0.808
RIF1	HEATR1	ENSSSCP00000017370	ENSSSCP00000010819	Replication timing regulatory factor 1.	HEAT repeat containing 1.	0.878