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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WEE2Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. (565 aa)    
Predicted Functional Partners:
CDK1
Cyclin-dependent kinase 1 isoform 1; Belongs to the protein kinase superfamily.
   
 0.975
CHEK1
Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily.
   
0.952
WEE1
Wee1-like protein kinase.
  
  
0.908
CDC25B
M-phase inducer phosphatase 2 isoform 1.
   
 
 0.762
RAD21
Double-strand-break repair protein rad21 homolog.
   
 
 0.745
CHEK2
Serine/threonine-protein kinase Chk2 isoform X4.
   
 
 0.742
CDC25A
M-phase inducer phosphatase 1 isoform a.
   
 
 0.697
CKAP5
Cytoskeleton associated protein 5.
    
   0.689
BTG4
BTG anti-proliferation factor 4.
   
  
 0.673
PRMT5
Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.
    
 
 0.664
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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