PARP12 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PARP12

Poly(ADP-ribose) polymerase family member 12. (702 aa)

Predicted Functional Partners:

PARP9

0.859

KHNYN

0.813

IFIH1

0.720

DHX58

0.713

EIF2AK2

0.710

CMPK2

0.707

DTX3L

0.687

ZNFX1

0.684

DDX58

0.653

MNDA

0.645

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMPK2	DDX58	ENSSSCP00000073978	ENSSSCP00000045260	Cytidine/uridine monophosphate kinase 2.	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	0.593
CMPK2	DHX58	ENSSSCP00000073978	ENSSSCP00000018455	Cytidine/uridine monophosphate kinase 2.	DExH-box helicase 58.	0.747
CMPK2	DTX3L	ENSSSCP00000073978	ENSSSCP00000026768	Cytidine/uridine monophosphate kinase 2.	Deltex E3 ubiquitin ligase 3L.	0.417
CMPK2	EIF2AK2	ENSSSCP00000073978	ENSSSCP00000057073	Cytidine/uridine monophosphate kinase 2.	Eukaryotic translation initiation factor 2 alpha kinase 2.	0.651
CMPK2	IFIH1	ENSSSCP00000073978	ENSSSCP00000044491	Cytidine/uridine monophosphate kinase 2.	Interferon induced with helicase C domain 1.	0.751
CMPK2	PARP12	ENSSSCP00000073978	ENSSSCP00000017484	Cytidine/uridine monophosphate kinase 2.	Poly(ADP-ribose) polymerase family member 12.	0.707
CMPK2	PARP9	ENSSSCP00000073978	ENSSSCP00000051232	Cytidine/uridine monophosphate kinase 2.	Poly(ADP-ribose) polymerase family member 9.	0.751
CMPK2	ZNFX1	ENSSSCP00000073978	ENSSSCP00000019450	Cytidine/uridine monophosphate kinase 2.	Zinc finger NFX1-type containing 1.	0.622
DDX58	CMPK2	ENSSSCP00000045260	ENSSSCP00000073978	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Cytidine/uridine monophosphate kinase 2.	0.593
DDX58	DHX58	ENSSSCP00000045260	ENSSSCP00000018455	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	DExH-box helicase 58.	0.989
DDX58	EIF2AK2	ENSSSCP00000045260	ENSSSCP00000057073	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Eukaryotic translation initiation factor 2 alpha kinase 2.	0.960
DDX58	IFIH1	ENSSSCP00000045260	ENSSSCP00000044491	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Interferon induced with helicase C domain 1.	0.957
DDX58	PARP12	ENSSSCP00000045260	ENSSSCP00000017484	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Poly(ADP-ribose) polymerase family member 12.	0.653
DDX58	PARP9	ENSSSCP00000045260	ENSSSCP00000051232	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	Poly(ADP-ribose) polymerase family member 9.	0.904
DHX58	CMPK2	ENSSSCP00000018455	ENSSSCP00000073978	DExH-box helicase 58.	Cytidine/uridine monophosphate kinase 2.	0.747
DHX58	DDX58	ENSSSCP00000018455	ENSSSCP00000045260	DExH-box helicase 58.	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	0.989
DHX58	DTX3L	ENSSSCP00000018455	ENSSSCP00000026768	DExH-box helicase 58.	Deltex E3 ubiquitin ligase 3L.	0.531
DHX58	EIF2AK2	ENSSSCP00000018455	ENSSSCP00000057073	DExH-box helicase 58.	Eukaryotic translation initiation factor 2 alpha kinase 2.	0.833
DHX58	IFIH1	ENSSSCP00000018455	ENSSSCP00000044491	DExH-box helicase 58.	Interferon induced with helicase C domain 1.	0.990
DHX58	PARP12	ENSSSCP00000018455	ENSSSCP00000017484	DExH-box helicase 58.	Poly(ADP-ribose) polymerase family member 12.	0.713