node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKMY1 | TBXAS1 | ENSSSCP00000049589 | ENSSSCP00000017486 | Uncharacterized protein. | Thromboxane-A synthase; Belongs to the cytochrome P450 family. | 0.607 |
HPGDS | PRXL2B | ENSSSCP00000009804 | ENSSSCP00000023293 | Hematopoietic prostaglandin D synthase. | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | 0.935 |
HPGDS | PTGDS | ENSSSCP00000009804 | ENSSSCP00000065625 | Hematopoietic prostaglandin D synthase. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.950 |
HPGDS | PTGES | ENSSSCP00000009804 | ENSSSCP00000006094 | Hematopoietic prostaglandin D synthase. | Microsomal prostaglandin E synthase-1. | 0.946 |
HPGDS | PTGES2 | ENSSSCP00000009804 | ENSSSCP00000006036 | Hematopoietic prostaglandin D synthase. | Prostaglandin E synthase 2. | 0.944 |
HPGDS | PTGES3 | ENSSSCP00000009804 | ENSSSCP00000000433 | Hematopoietic prostaglandin D synthase. | Prostaglandin E synthase 3. | 0.940 |
HPGDS | PTGIS | ENSSSCP00000009804 | ENSSSCP00000007951 | Hematopoietic prostaglandin D synthase. | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. | 0.927 |
HPGDS | PTGS1 | ENSSSCP00000009804 | ENSSSCP00000045461 | Hematopoietic prostaglandin D synthase. | Prostaglandin G/H synthase 1 isoform 1. | 0.948 |
HPGDS | PTGS2 | ENSSSCP00000009804 | ENSSSCP00000035355 | Hematopoietic prostaglandin D synthase. | Prostaglandin G/H synthase 2. | 0.936 |
HPGDS | TBXAS1 | ENSSSCP00000009804 | ENSSSCP00000017486 | Hematopoietic prostaglandin D synthase. | Thromboxane-A synthase; Belongs to the cytochrome P450 family. | 0.947 |
PRXL2B | HPGDS | ENSSSCP00000023293 | ENSSSCP00000009804 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Hematopoietic prostaglandin D synthase. | 0.935 |
PRXL2B | PTGDS | ENSSSCP00000023293 | ENSSSCP00000065625 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.908 |
PRXL2B | PTGES | ENSSSCP00000023293 | ENSSSCP00000006094 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Microsomal prostaglandin E synthase-1. | 0.920 |
PRXL2B | PTGES2 | ENSSSCP00000023293 | ENSSSCP00000006036 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Prostaglandin E synthase 2. | 0.908 |
PRXL2B | PTGES3 | ENSSSCP00000023293 | ENSSSCP00000000433 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Prostaglandin E synthase 3. | 0.900 |
PRXL2B | PTGIS | ENSSSCP00000023293 | ENSSSCP00000007951 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. | 0.901 |
PRXL2B | PTGS1 | ENSSSCP00000023293 | ENSSSCP00000045461 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Prostaglandin G/H synthase 1 isoform 1. | 0.911 |
PRXL2B | PTGS2 | ENSSSCP00000023293 | ENSSSCP00000035355 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Prostaglandin G/H synthase 2. | 0.916 |
PRXL2B | TBXAS1 | ENSSSCP00000023293 | ENSSSCP00000017486 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). | Thromboxane-A synthase; Belongs to the cytochrome P450 family. | 0.902 |
PTGDS | HPGDS | ENSSSCP00000065625 | ENSSSCP00000009804 | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | Hematopoietic prostaglandin D synthase. | 0.950 |