Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TBXAS1Thromboxane-A synthase; Belongs to the cytochrome P450 family. (535 aa)    
Predicted Functional Partners:
PTGIS
Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family.
   
 
 0.973
PTGS1
Prostaglandin G/H synthase 1 isoform 1.
   
 
 0.970
PTGES2
Prostaglandin E synthase 2.
     
 0.959
HPGDS
Hematopoietic prostaglandin D synthase.
   
 
 0.954
PTGES
Microsomal prostaglandin E synthase-1.
   
 
 0.952
PTGS2
Prostaglandin G/H synthase 2.
   
 
 0.941
PTGDS
Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...]
   
 
 0.913
PTGES3
Prostaglandin E synthase 3.
   
 
 0.905
PRXL2B
Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha).
     
 0.892
MED30
Mediator of RNA polymerase II transcription subunit 30 isoform 1.
   
 0.771
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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