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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
a 3D structure is known or predicted
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METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)    
Predicted Functional Partners:
HGF
Hepatocyte growth factor; Belongs to the peptidase S1 family.
    
 0.999
GRB2
Growth factor receptor-bound protein 2 isoform 1.
    
 0.997
CBL
Cbl proto-oncogene.
    
 0.997
PLXNB1
Plexin B1.
    
0.996
PTPN1
Tyrosine-protein phosphatase non-receptor type.
    
 0.995
GAB1
GRB2 associated binding protein 1.
    
 0.992
EGFR
Receptor protein-tyrosine kinase.
   
0.991
SRC
Tyrosine-protein kinase.
   
0.985
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.977
CRK
CRK proto-oncogene, adaptor protein.
   
 0.971
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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