node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCT | MC1R | ENSSSCP00000010135 | ENSSSCP00000027395 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | 0.689 |
DCT | MLANA | ENSSSCP00000010135 | ENSSSCP00000005596 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Melanoma antigen recognized by T-cells 1. | 0.785 |
DCT | SLC24A5 | ENSSSCP00000010135 | ENSSSCP00000005022 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.611 |
DCT | SLC45A2 | ENSSSCP00000010135 | ENSSSCP00000070836 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Membrane-associated transporter protein; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity); Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.701 |
DCT | TYR | ENSSSCP00000010135 | ENSSSCP00000028210 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Tyrosinase. | 0.734 |
DCT | TYRP1 | ENSSSCP00000010135 | ENSSSCP00000005583 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 5,6-dihydroxyindole-2-carboxylic acid oxidase. | 0.937 |
GPNMB | SLC24A5 | ENSSSCP00000031610 | ENSSSCP00000005022 | Glycoprotein nmb. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.441 |
GPNMB | SLC45A2 | ENSSSCP00000031610 | ENSSSCP00000070836 | Glycoprotein nmb. | Membrane-associated transporter protein; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity); Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.624 |
GPNMB | TYR | ENSSSCP00000031610 | ENSSSCP00000028210 | Glycoprotein nmb. | Tyrosinase. | 0.594 |
MC1R | DCT | ENSSSCP00000027395 | ENSSSCP00000010135 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.689 |
MC1R | MLANA | ENSSSCP00000027395 | ENSSSCP00000005596 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | Melanoma antigen recognized by T-cells 1. | 0.412 |
MC1R | RAB38 | ENSSSCP00000027395 | ENSSSCP00000055022 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Belongs to the small GTPase superfam [...] | 0.438 |
MC1R | SLC24A5 | ENSSSCP00000027395 | ENSSSCP00000005022 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.618 |
MC1R | SLC36A1 | ENSSSCP00000027395 | ENSSSCP00000056869 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | Solute carrier family 36 member 1. | 0.420 |
MC1R | SLC45A2 | ENSSSCP00000027395 | ENSSSCP00000070836 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | Membrane-associated transporter protein; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity); Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.680 |
MC1R | TYR | ENSSSCP00000027395 | ENSSSCP00000028210 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | Tyrosinase. | 0.809 |
MC1R | TYRP1 | ENSSSCP00000027395 | ENSSSCP00000005583 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | 5,6-dihydroxyindole-2-carboxylic acid oxidase. | 0.879 |
MLANA | DCT | ENSSSCP00000005596 | ENSSSCP00000010135 | Melanoma antigen recognized by T-cells 1. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.785 |
MLANA | MC1R | ENSSSCP00000005596 | ENSSSCP00000027395 | Melanoma antigen recognized by T-cells 1. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | 0.412 |
MLANA | SLC24A5 | ENSSSCP00000005596 | ENSSSCP00000005022 | Melanoma antigen recognized by T-cells 1. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.771 |