node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADSL | COASY | ENSSSCP00000000082 | ENSSSCP00000060476 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | 0.782 |
ADSL | DCAKD | ENSSSCP00000000082 | ENSSSCP00000051876 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Dephospho-CoA kinase domain containing. | 0.777 |
ADSL | RRM1 | ENSSSCP00000000082 | ENSSSCP00000040138 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.588 |
CCDC30 | COASY | ENSSSCP00000035379 | ENSSSCP00000060476 | Uncharacterized protein. | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | 0.907 |
CCDC30 | COX19 | ENSSSCP00000035379 | ENSSSCP00000046242 | Uncharacterized protein. | Cytochrome c oxidase assembly factor COX19. | 0.663 |
CCDC30 | DCAKD | ENSSSCP00000035379 | ENSSSCP00000051876 | Uncharacterized protein. | Dephospho-CoA kinase domain containing. | 0.491 |
CCDC30 | PANK3 | ENSSSCP00000035379 | ENSSSCP00000044681 | Uncharacterized protein. | Pantothenate kinase 3. | 0.659 |
CCDC30 | PANK4 | ENSSSCP00000035379 | ENSSSCP00000026165 | Uncharacterized protein. | 4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. | 0.843 |
CCDC30 | PPCDC | ENSSSCP00000035379 | ENSSSCP00000054089 | Uncharacterized protein. | Phosphopantothenoylcysteine decarboxylase. | 0.800 |
COASY | ADSL | ENSSSCP00000060476 | ENSSSCP00000000082 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.782 |
COASY | CCDC30 | ENSSSCP00000060476 | ENSSSCP00000035379 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | Uncharacterized protein. | 0.907 |
COASY | COX19 | ENSSSCP00000060476 | ENSSSCP00000046242 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | Cytochrome c oxidase assembly factor COX19. | 0.906 |
COASY | DCAKD | ENSSSCP00000060476 | ENSSSCP00000051876 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | Dephospho-CoA kinase domain containing. | 0.857 |
COASY | MLX | ENSSSCP00000060476 | ENSSSCP00000060336 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | MAX dimerization protein MLX. | 0.743 |
COASY | PANK3 | ENSSSCP00000060476 | ENSSSCP00000044681 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | Pantothenate kinase 3. | 0.758 |
COASY | PANK4 | ENSSSCP00000060476 | ENSSSCP00000026165 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | 4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. | 0.777 |
COASY | PPCDC | ENSSSCP00000060476 | ENSSSCP00000054089 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | Phosphopantothenoylcysteine decarboxylase. | 0.955 |
COASY | PPCS | ENSSSCP00000060476 | ENSSSCP00000004287 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | Phosphopantothenoylcysteine synthetase. | 0.969 |
COASY | RRM1 | ENSSSCP00000060476 | ENSSSCP00000040138 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.760 |
COX19 | CCDC30 | ENSSSCP00000046242 | ENSSSCP00000035379 | Cytochrome c oxidase assembly factor COX19. | Uncharacterized protein. | 0.663 |