node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL2 | CCL4 | ENSSSCP00000018779 | ENSSSCP00000067744 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | 0.996 |
CCL2 | CCR1 | ENSSSCP00000018779 | ENSSSCP00000012073 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.943 |
CCL2 | CCR2 | ENSSSCP00000018779 | ENSSSCP00000024949 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
CCL2 | CCR5 | ENSSSCP00000018779 | ENSSSCP00000072998 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. | 0.956 |
CCL2 | CXCL10 | ENSSSCP00000018779 | ENSSSCP00000032297 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine. | 0.943 |
CCL2 | CXCL13 | ENSSSCP00000018779 | ENSSSCP00000039756 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine. | 0.985 |
CCL2 | CXCR3 | ENSSSCP00000018779 | ENSSSCP00000029108 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C chemokine receptor type 3 isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.945 |
CCL2 | CXCR4 | ENSSSCP00000018779 | ENSSSCP00000058444 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.966 |
CCL2 | IL6 | ENSSSCP00000018779 | ENSSSCP00000023819 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.971 |
CCL4 | CCL2 | ENSSSCP00000067744 | ENSSSCP00000018779 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | 0.996 |
CCL4 | CCR1 | ENSSSCP00000067744 | ENSSSCP00000012073 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.940 |
CCL4 | CCR2 | ENSSSCP00000067744 | ENSSSCP00000024949 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. | 0.946 |
CCL4 | CCR5 | ENSSSCP00000067744 | ENSSSCP00000072998 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. | 0.988 |
CCL4 | CXCL10 | ENSSSCP00000067744 | ENSSSCP00000032297 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C motif chemokine. | 0.933 |
CCL4 | CXCL13 | ENSSSCP00000067744 | ENSSSCP00000039756 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C motif chemokine. | 0.989 |
CCL4 | CXCR3 | ENSSSCP00000067744 | ENSSSCP00000029108 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C chemokine receptor type 3 isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.933 |
CCL4 | CXCR4 | ENSSSCP00000067744 | ENSSSCP00000058444 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.924 |
CCL4 | IL6 | ENSSSCP00000067744 | ENSSSCP00000023819 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.918 |
CCL4 | IRF5 | ENSSSCP00000067744 | ENSSSCP00000040010 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | Interferon regulatory factor 5 isoform X2. | 0.917 |
CCR1 | CCL2 | ENSSSCP00000012073 | ENSSSCP00000018779 | Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | 0.943 |