| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | CDKN1A | ENSSSCP00000015931 | ENSSSCP00000001700 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | Cyclin dependent kinase inhibitor 1A. | 0.582 |
| ATM | CHEK1 | ENSSSCP00000015931 | ENSSSCP00000016136 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. | 0.995 |
| ATM | CHEK2 | ENSSSCP00000015931 | ENSSSCP00000039835 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | Serine/threonine-protein kinase Chk2 isoform X4. | 0.999 |
| ATM | MDM2 | ENSSSCP00000015931 | ENSSSCP00000054644 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.979 |
| ATM | MDM4 | ENSSSCP00000015931 | ENSSSCP00000016209 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | MDM4 regulator of p53. | 0.721 |
| ATM | SIRT1 | ENSSSCP00000015931 | ENSSSCP00000010911 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | NAD-dependent protein deacetylase sirtuin-1 isoform a. | 0.508 |
| ATM | TP53 | ENSSSCP00000015931 | ENSSSCP00000050664 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.999 |
| ATM | USP7 | ENSSSCP00000015931 | ENSSSCP00000008441 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.419 |
| CDKN1A | ATM | ENSSSCP00000001700 | ENSSSCP00000015931 | Cyclin dependent kinase inhibitor 1A. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | 0.582 |
| CDKN1A | CHEK1 | ENSSSCP00000001700 | ENSSSCP00000016136 | Cyclin dependent kinase inhibitor 1A. | Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. | 0.488 |
| CDKN1A | CHEK2 | ENSSSCP00000001700 | ENSSSCP00000039835 | Cyclin dependent kinase inhibitor 1A. | Serine/threonine-protein kinase Chk2 isoform X4. | 0.515 |
| CDKN1A | CREBBP | ENSSSCP00000001700 | ENSSSCP00000008490 | Cyclin dependent kinase inhibitor 1A. | CREB-binding protein isoform a. | 0.857 |
| CDKN1A | EP300 | ENSSSCP00000001700 | ENSSSCP00000020812 | Cyclin dependent kinase inhibitor 1A. | E1A binding protein p300. | 0.877 |
| CDKN1A | MDM2 | ENSSSCP00000001700 | ENSSSCP00000054644 | Cyclin dependent kinase inhibitor 1A. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.972 |
| CDKN1A | MDM4 | ENSSSCP00000001700 | ENSSSCP00000016209 | Cyclin dependent kinase inhibitor 1A. | MDM4 regulator of p53. | 0.650 |
| CDKN1A | SIRT1 | ENSSSCP00000001700 | ENSSSCP00000010911 | Cyclin dependent kinase inhibitor 1A. | NAD-dependent protein deacetylase sirtuin-1 isoform a. | 0.412 |
| CDKN1A | TP53 | ENSSSCP00000001700 | ENSSSCP00000050664 | Cyclin dependent kinase inhibitor 1A. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.998 |
| CHEK1 | ATM | ENSSSCP00000016136 | ENSSSCP00000015931 | Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] | 0.995 |
| CHEK1 | CDKN1A | ENSSSCP00000016136 | ENSSSCP00000001700 | Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. | Cyclin dependent kinase inhibitor 1A. | 0.488 |
| CHEK1 | CHEK2 | ENSSSCP00000016136 | ENSSSCP00000039835 | Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase Chk2 isoform X4. | 0.992 |
