Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GRB10 | IGF1R | ENSSSCP00000031279 | ENSSSCP00000005181 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Tyrosine-protein kinase receptor. | 0.980 |
| GRB10 | IGF2R | ENSSSCP00000031279 | ENSSSCP00000004370 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Insulin-like growth factor II receptor. | 0.804 |
| GRB10 | INS | ENSSSCP00000031279 | ENSSSCP00000044635 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.792 |
| GRB10 | INSR | ENSSSCP00000031279 | ENSSSCP00000014414 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Tyrosine-protein kinase receptor. | 0.973 |
| GRB10 | IRS1 | ENSSSCP00000031279 | ENSSSCP00000061240 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Insulin receptor substrate 1. | 0.754 |
| GRB10 | MTOR | ENSSSCP00000031279 | ENSSSCP00000003699 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.914 |
| GRB10 | NEDD4 | ENSSSCP00000031279 | ENSSSCP00000056304 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | E3 ubiquitin-protein ligase NEDD4 isoform 3. | 0.862 |
| GRB10 | PIK3CA | ENSSSCP00000031279 | ENSSSCP00000052984 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.808 |
| GRB10 | PIK3R1 | ENSSSCP00000031279 | ENSSSCP00000024885 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Phosphoinositide-3-kinase regulatory subunit 1. | 0.888 |
| GRB10 | PLAG1 | ENSSSCP00000031279 | ENSSSCP00000006660 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | PLAG1 zinc finger. | 0.791 |
| IGF1R | GRB10 | ENSSSCP00000005181 | ENSSSCP00000031279 | Tyrosine-protein kinase receptor. | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | 0.980 |
| IGF1R | IGF2R | ENSSSCP00000005181 | ENSSSCP00000004370 | Tyrosine-protein kinase receptor. | Insulin-like growth factor II receptor. | 0.918 |
| IGF1R | INS | ENSSSCP00000005181 | ENSSSCP00000044635 | Tyrosine-protein kinase receptor. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.998 |
| IGF1R | INSR | ENSSSCP00000005181 | ENSSSCP00000014414 | Tyrosine-protein kinase receptor. | Tyrosine-protein kinase receptor. | 0.985 |
| IGF1R | IRS1 | ENSSSCP00000005181 | ENSSSCP00000061240 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 1. | 0.988 |
| IGF1R | NEDD4 | ENSSSCP00000005181 | ENSSSCP00000056304 | Tyrosine-protein kinase receptor. | E3 ubiquitin-protein ligase NEDD4 isoform 3. | 0.802 |
| IGF1R | PIK3CA | ENSSSCP00000005181 | ENSSSCP00000052984 | Tyrosine-protein kinase receptor. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.961 |
| IGF1R | PIK3R1 | ENSSSCP00000005181 | ENSSSCP00000024885 | Tyrosine-protein kinase receptor. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.697 |
| IGF2R | GRB10 | ENSSSCP00000004370 | ENSSSCP00000031279 | Insulin-like growth factor II receptor. | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | 0.804 |
| IGF2R | IGF1R | ENSSSCP00000004370 | ENSSSCP00000005181 | Insulin-like growth factor II receptor. | Tyrosine-protein kinase receptor. | 0.918 |
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