| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHCY | AHCYL1 | ENSSSCP00000071725 | ENSSSCP00000032595 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | 0.967 |
| AHCY | AHCYL2 | ENSSSCP00000071725 | ENSSSCP00000017552 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. | 0.967 |
| AHCY | BHMT | ENSSSCP00000071725 | ENSSSCP00000074281 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. | 0.975 |
| AHCY | CBS | ENSSSCP00000071725 | ENSSSCP00000046337 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.958 |
| AHCY | CTH | ENSSSCP00000071725 | ENSSSCP00000004099 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.939 |
| AHCY | MAT1A | ENSSSCP00000071725 | ENSSSCP00000011024 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.633 |
| AHCY | MAT2A | ENSSSCP00000071725 | ENSSSCP00000037794 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.667 |
| AHCY | MAT2B | ENSSSCP00000071725 | ENSSSCP00000066139 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.412 |
| AHCY | MTR | ENSSSCP00000071725 | ENSSSCP00000010817 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.969 |
| AHCYL1 | AHCY | ENSSSCP00000032595 | ENSSSCP00000071725 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | 0.967 |
| AHCYL1 | AHCYL2 | ENSSSCP00000032595 | ENSSSCP00000017552 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. | 0.926 |
| AHCYL1 | BHMT | ENSSSCP00000032595 | ENSSSCP00000074281 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. | 0.972 |
| AHCYL1 | CBS | ENSSSCP00000032595 | ENSSSCP00000046337 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.962 |
| AHCYL1 | CTH | ENSSSCP00000032595 | ENSSSCP00000004099 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.956 |
| AHCYL1 | MAT1A | ENSSSCP00000032595 | ENSSSCP00000011024 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.595 |
| AHCYL1 | MAT2A | ENSSSCP00000032595 | ENSSSCP00000037794 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.655 |
| AHCYL1 | MAT2B | ENSSSCP00000032595 | ENSSSCP00000066139 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.681 |
| AHCYL1 | MTR | ENSSSCP00000032595 | ENSSSCP00000010817 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.963 |
| AHCYL2 | AHCY | ENSSSCP00000017552 | ENSSSCP00000071725 | Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | 0.967 |
| AHCYL2 | AHCYL1 | ENSSSCP00000017552 | ENSSSCP00000032595 | Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. | 0.926 |
