CDH3 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARVCF	CDH3	ENSSSCP00000058566	ENSSSCP00000021843	ARVCF delta catenin family member.	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	0.786
ARVCF	CTNNA1	ENSSSCP00000058566	ENSSSCP00000015253	ARVCF delta catenin family member.	Catenin alpha 1.	0.528
ARVCF	CTNNA2	ENSSSCP00000058566	ENSSSCP00000027970	ARVCF delta catenin family member.	Uncharacterized protein.	0.528
ARVCF	CTNNB1	ENSSSCP00000058566	ENSSSCP00000031836	ARVCF delta catenin family member.	Catenin beta 1.	0.840
ARVCF	EGFR	ENSSSCP00000058566	ENSSSCP00000068369	ARVCF delta catenin family member.	Receptor protein-tyrosine kinase.	0.585
ARVCF	JUP	ENSSSCP00000058566	ENSSSCP00000018469	ARVCF delta catenin family member.	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	0.640
ARVCF	VCL	ENSSSCP00000058566	ENSSSCP00000010997	ARVCF delta catenin family member.	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	0.410
CDC27	CDH3	ENSSSCP00000056229	ENSSSCP00000021843	Cell division cycle 27.	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	0.746
CDC27	SKP2	ENSSSCP00000056229	ENSSSCP00000017834	Cell division cycle 27.	S-phase kinase-associated protein 2 isoform 1.	0.675
CDH3	ARVCF	ENSSSCP00000021843	ENSSSCP00000058566	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	ARVCF delta catenin family member.	0.786
CDH3	CDC27	ENSSSCP00000021843	ENSSSCP00000056229	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	Cell division cycle 27.	0.746
CDH3	CTNNA1	ENSSSCP00000021843	ENSSSCP00000015253	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	Catenin alpha 1.	0.729
CDH3	CTNNA2	ENSSSCP00000021843	ENSSSCP00000027970	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	Uncharacterized protein.	0.708
CDH3	CTNNB1	ENSSSCP00000021843	ENSSSCP00000031836	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	Catenin beta 1.	0.977
CDH3	CTNND1	ENSSSCP00000021843	ENSSSCP00000014004	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	Catenin delta 1.	0.969
CDH3	EGFR	ENSSSCP00000021843	ENSSSCP00000068369	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	Receptor protein-tyrosine kinase.	0.729
CDH3	JUP	ENSSSCP00000021843	ENSSSCP00000018469	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	0.971
CDH3	SKP2	ENSSSCP00000021843	ENSSSCP00000017834	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	S-phase kinase-associated protein 2 isoform 1.	0.740
CDH3	VCL	ENSSSCP00000021843	ENSSSCP00000010997	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	0.798
CTNNA1	ARVCF	ENSSSCP00000015253	ENSSSCP00000058566	Catenin alpha 1.	ARVCF delta catenin family member.	0.528