node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCF1 | ERO1A | ENSSSCP00000028530 | ENSSSCP00000051791 | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...] | 0.476 |
ABCF1 | H2AC1 | ENSSSCP00000028530 | ENSSSCP00000074000 | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | Histone H2A; Belongs to the histone H2A family. | 0.554 |
ABCF1 | MOG | ENSSSCP00000028530 | ENSSSCP00000071377 | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | Myelin-oligodendrocyte glycoprotein; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.499 |
ABCF1 | RNF39 | ENSSSCP00000028530 | ENSSSCP00000022089 | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | Uncharacterized protein. | 0.844 |
ABCF1 | TCF19 | ENSSSCP00000028530 | ENSSSCP00000030891 | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. | 0.881 |
ABCF1 | ZNRD1 | ENSSSCP00000028530 | ENSSSCP00000057803 | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.699 |
ERO1A | ABCF1 | ENSSSCP00000051791 | ENSSSCP00000028530 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...] | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | 0.476 |
ERO1A | RNF39 | ENSSSCP00000051791 | ENSSSCP00000022089 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...] | Uncharacterized protein. | 0.546 |
ERO1A | TCF19 | ENSSSCP00000051791 | ENSSSCP00000030891 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...] | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. | 0.557 |
FAR2 | RNF39 | ENSSSCP00000049639 | ENSSSCP00000022089 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. | Uncharacterized protein. | 0.571 |
H2AC1 | ABCF1 | ENSSSCP00000074000 | ENSSSCP00000028530 | Histone H2A; Belongs to the histone H2A family. | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | 0.554 |
H2AC1 | RNF39 | ENSSSCP00000074000 | ENSSSCP00000022089 | Histone H2A; Belongs to the histone H2A family. | Uncharacterized protein. | 0.748 |
H2AC1 | TCF19 | ENSSSCP00000074000 | ENSSSCP00000030891 | Histone H2A; Belongs to the histone H2A family. | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. | 0.660 |
H2AC1 | ZNRD1 | ENSSSCP00000074000 | ENSSSCP00000057803 | Histone H2A; Belongs to the histone H2A family. | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.816 |
IL28B | RNF39 | ENSSSCP00000030147 | ENSSSCP00000022089 | Interleukin 28B (interferon, lambda 3). | Uncharacterized protein. | 0.550 |
IL28B | ZNRD1 | ENSSSCP00000030147 | ENSSSCP00000057803 | Interleukin 28B (interferon, lambda 3). | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.531 |
LOC110255217 | RNF39 | ENSSSCP00000011416 | ENSSSCP00000022089 | Uncharacterized protein. | Uncharacterized protein. | 0.550 |
LOC110255217 | ZNRD1 | ENSSSCP00000011416 | ENSSSCP00000057803 | Uncharacterized protein. | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.530 |
MOG | ABCF1 | ENSSSCP00000071377 | ENSSSCP00000028530 | Myelin-oligodendrocyte glycoprotein; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Belongs to the immunoglobulin superfamily. BTN/MOG family. | ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. | 0.499 |
MOG | RNF39 | ENSSSCP00000071377 | ENSSSCP00000022089 | Myelin-oligodendrocyte glycoprotein; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Belongs to the immunoglobulin superfamily. BTN/MOG family. | Uncharacterized protein. | 0.591 |