node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCND1 | CCND2 | ENSSSCP00000059262 | ENSSSCP00000053383 | Cyclin D1; Belongs to the cyclin family. | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.920 |
CCND1 | CCND3 | ENSSSCP00000059262 | ENSSSCP00000061232 | Cyclin D1; Belongs to the cyclin family. | Cyclin D3; Belongs to the cyclin family. | 0.562 |
CCND1 | CCNE1 | ENSSSCP00000059262 | ENSSSCP00000003075 | Cyclin D1; Belongs to the cyclin family. | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | 0.764 |
CCND1 | CDC25A | ENSSSCP00000059262 | ENSSSCP00000050712 | Cyclin D1; Belongs to the cyclin family. | M-phase inducer phosphatase 1 isoform a. | 0.966 |
CCND1 | CDK4 | ENSSSCP00000059262 | ENSSSCP00000022407 | Cyclin D1; Belongs to the cyclin family. | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] | 0.999 |
CCND1 | CDKN1A | ENSSSCP00000059262 | ENSSSCP00000001700 | Cyclin D1; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 1A. | 0.998 |
CCND1 | CDKN1B | ENSSSCP00000059262 | ENSSSCP00000045015 | Cyclin D1; Belongs to the cyclin family. | p27Kip1. | 0.988 |
CCND1 | CDKN2B | ENSSSCP00000059262 | ENSSSCP00000005517 | Cyclin D1; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 2B. | 0.950 |
CCND1 | CDKN2C | ENSSSCP00000059262 | ENSSSCP00000004189 | Cyclin D1; Belongs to the cyclin family. | Cyclin-dependent kinase 4 inhibitor C. | 0.951 |
CCND1 | RB1 | ENSSSCP00000059262 | ENSSSCP00000010032 | Cyclin D1; Belongs to the cyclin family. | RB transcriptional corepressor 1. | 0.986 |
CCND2 | CCND1 | ENSSSCP00000053383 | ENSSSCP00000059262 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin D1; Belongs to the cyclin family. | 0.920 |
CCND2 | CCND3 | ENSSSCP00000053383 | ENSSSCP00000061232 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin D3; Belongs to the cyclin family. | 0.428 |
CCND2 | CDC25A | ENSSSCP00000053383 | ENSSSCP00000050712 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | M-phase inducer phosphatase 1 isoform a. | 0.942 |
CCND2 | CDK4 | ENSSSCP00000053383 | ENSSSCP00000022407 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] | 0.998 |
CCND2 | CDKN1A | ENSSSCP00000053383 | ENSSSCP00000001700 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase inhibitor 1A. | 0.979 |
CCND2 | CDKN1B | ENSSSCP00000053383 | ENSSSCP00000045015 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | p27Kip1. | 0.975 |
CCND2 | CDKN2B | ENSSSCP00000053383 | ENSSSCP00000005517 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase inhibitor 2B. | 0.943 |
CCND2 | CDKN2C | ENSSSCP00000053383 | ENSSSCP00000004189 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin-dependent kinase 4 inhibitor C. | 0.949 |
CCND2 | RB1 | ENSSSCP00000053383 | ENSSSCP00000010032 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | RB transcriptional corepressor 1. | 0.955 |
CCND3 | CCND1 | ENSSSCP00000061232 | ENSSSCP00000059262 | Cyclin D3; Belongs to the cyclin family. | Cyclin D1; Belongs to the cyclin family. | 0.562 |