node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAX | RGN | ENSSSCP00000003404 | ENSSSCP00000023581 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Belongs to the SMP-30/CGR1 family. | 0.756 |
BAX | SORD | ENSSSCP00000003404 | ENSSSCP00000047058 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.586 |
BLVRA | RGN | ENSSSCP00000057619 | ENSSSCP00000023581 | Biliverdin reductase A. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Belongs to the SMP-30/CGR1 family. | 0.715 |
BLVRA | SORD | ENSSSCP00000057619 | ENSSSCP00000047058 | Biliverdin reductase A. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.529 |
CAT | PARK7 | ENSSSCP00000014135 | ENSSSCP00000003670 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | DJ-1 protein. | 0.669 |
CAT | RGN | ENSSSCP00000014135 | ENSSSCP00000023581 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Belongs to the SMP-30/CGR1 family. | 0.852 |
CAT | SORD | ENSSSCP00000014135 | ENSSSCP00000047058 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.488 |
CHDH | IDNK | ENSSSCP00000032590 | ENSSSCP00000038284 | Choline dehydrogenase. | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. | 0.641 |
CHDH | RGN | ENSSSCP00000032590 | ENSSSCP00000023581 | Choline dehydrogenase. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Belongs to the SMP-30/CGR1 family. | 0.837 |
CHDH | SORD | ENSSSCP00000032590 | ENSSSCP00000047058 | Choline dehydrogenase. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.529 |
GULO | RGN | ENSSSCP00000072209 | ENSSSCP00000023581 | L-gulonolactone oxidase; Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L- xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Belongs to the SMP-30/CGR1 family. | 0.966 |
HEATR6 | RGN | ENSSSCP00000055946 | ENSSSCP00000023581 | HEAT repeat containing 6. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Belongs to the SMP-30/CGR1 family. | 0.847 |
IDNK | CHDH | ENSSSCP00000038284 | ENSSSCP00000032590 | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. | Choline dehydrogenase. | 0.641 |
IDNK | IFT46 | ENSSSCP00000038284 | ENSSSCP00000063545 | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. | Intraflagellar transport 46. | 0.641 |
IDNK | RGN | ENSSSCP00000038284 | ENSSSCP00000023581 | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Belongs to the SMP-30/CGR1 family. | 0.986 |
IDNK | SORD | ENSSSCP00000038284 | ENSSSCP00000047058 | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.535 |
IFT46 | IDNK | ENSSSCP00000063545 | ENSSSCP00000038284 | Intraflagellar transport 46. | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. | 0.641 |
IFT46 | RGN | ENSSSCP00000063545 | ENSSSCP00000023581 | Intraflagellar transport 46. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Belongs to the SMP-30/CGR1 family. | 0.837 |
IFT46 | SORD | ENSSSCP00000063545 | ENSSSCP00000047058 | Intraflagellar transport 46. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.529 |
PARK7 | CAT | ENSSSCP00000003670 | ENSSSCP00000014135 | DJ-1 protein. | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | 0.669 |