HOMEZ protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HOMEZ

Homeobox and leucine zipper encoding. (639 aa)

Predicted Functional Partners:

TBC1D31

0.693

FAM83A

0.670

RAB5IF

0.669

FOXB1

0.554

ALOX5

0.524

BARHL1

0.523

ZSCAN26

0.518

GGT7

0.516

ZHX3

0.506

DHX35

0.506

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALOX5	HOMEZ	ENSSSCP00000030319	ENSSSCP00000024229	Arachidonate 5-lipoxygenase.	Homeobox and leucine zipper encoding.	0.524
BARHL1	HOMEZ	ENSSSCP00000006139	ENSSSCP00000024229	BarH like homeobox 1.	Homeobox and leucine zipper encoding.	0.523
DHX35	FAM83A	ENSSSCP00000059747	ENSSSCP00000006394	Putative ATP-dependent RNA helicase DHX35 isoform 1.	Family with sequence similarity 83 member A.	0.764
DHX35	GGT7	ENSSSCP00000059747	ENSSSCP00000007757	Putative ATP-dependent RNA helicase DHX35 isoform 1.	Gamma-glutamyltransferase 7.	0.727
DHX35	HOMEZ	ENSSSCP00000059747	ENSSSCP00000024229	Putative ATP-dependent RNA helicase DHX35 isoform 1.	Homeobox and leucine zipper encoding.	0.506
DHX35	RAB5IF	ENSSSCP00000059747	ENSSSCP00000039753	Putative ATP-dependent RNA helicase DHX35 isoform 1.	TGIF2-RAB5IF readthrough.	0.818
DHX35	TBC1D31	ENSSSCP00000059747	ENSSSCP00000056189	Putative ATP-dependent RNA helicase DHX35 isoform 1.	TBC1 domain family member 31.	0.815
DHX35	ZHX3	ENSSSCP00000059747	ENSSSCP00000044175	Putative ATP-dependent RNA helicase DHX35 isoform 1.	Zinc fingers and homeoboxes protein 3 isoform X3.	0.782
FAM83A	DHX35	ENSSSCP00000006394	ENSSSCP00000059747	Family with sequence similarity 83 member A.	Putative ATP-dependent RNA helicase DHX35 isoform 1.	0.764
FAM83A	GGT7	ENSSSCP00000006394	ENSSSCP00000007757	Family with sequence similarity 83 member A.	Gamma-glutamyltransferase 7.	0.787
FAM83A	HOMEZ	ENSSSCP00000006394	ENSSSCP00000024229	Family with sequence similarity 83 member A.	Homeobox and leucine zipper encoding.	0.670
FAM83A	RAB5IF	ENSSSCP00000006394	ENSSSCP00000039753	Family with sequence similarity 83 member A.	TGIF2-RAB5IF readthrough.	0.879
FAM83A	TBC1D31	ENSSSCP00000006394	ENSSSCP00000056189	Family with sequence similarity 83 member A.	TBC1 domain family member 31.	0.902
FAM83A	ZHX3	ENSSSCP00000006394	ENSSSCP00000044175	Family with sequence similarity 83 member A.	Zinc fingers and homeoboxes protein 3 isoform X3.	0.863
FOXB1	HOMEZ	ENSSSCP00000045510	ENSSSCP00000024229	Forkhead box protein B1.	Homeobox and leucine zipper encoding.	0.554
GGT7	DHX35	ENSSSCP00000007757	ENSSSCP00000059747	Gamma-glutamyltransferase 7.	Putative ATP-dependent RNA helicase DHX35 isoform 1.	0.727
GGT7	FAM83A	ENSSSCP00000007757	ENSSSCP00000006394	Gamma-glutamyltransferase 7.	Family with sequence similarity 83 member A.	0.787
GGT7	HOMEZ	ENSSSCP00000007757	ENSSSCP00000024229	Gamma-glutamyltransferase 7.	Homeobox and leucine zipper encoding.	0.516
GGT7	RAB5IF	ENSSSCP00000007757	ENSSSCP00000039753	Gamma-glutamyltransferase 7.	TGIF2-RAB5IF readthrough.	0.836
GGT7	TBC1D31	ENSSSCP00000007757	ENSSSCP00000056189	Gamma-glutamyltransferase 7.	TBC1 domain family member 31.	0.826

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

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