STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (589 aa)    
Predicted Functional Partners:
TBK1
TANK binding kinase TBK1.
   
 0.943
GABARAPL1
Uncharacterized protein.
    
 0.929
GABARAP
Uncharacterized protein.
    
 0.914
GABARAPL2
Uncharacterized protein.
    
 0.911
CHUK
Protein kinase domain-containing protein.
    
 0.790
RAB8A
Uncharacterized protein.
     
 0.772
RAB8B
RAB8B, member RAS oncogene family.
     
 0.772
PLK1
Serine/threonine-protein kinase PLK.
     
  0.750
OFD1
Oral-facial-digital syndrome 1 protein.
  
 
 0.680
IKBKB
Inhibitor of kappa light chain gene enhancer in B cells, kinase beta.
    
 
 0.665
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.