STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
DEFB1-2Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (64 aa)    
Predicted Functional Partners:
DEFB1
Beta-defensin 1.
   
 
 0.990
NPG1
Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family.
   
  
 0.786
LOC110255221
Antibacterial peptide PMAP-37; Exerts antimicrobial activity against both Gram-positive and negative bacteria with minimal inhibitory concentrations ranging over 1-4 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes; Belongs to the cathelicidin family.
   
  
 0.768
CCR2
C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family.
     
 0.732
PMAP-36
Antibacterial peptide PMAP-36; Exerts antimicrobial activity against both Gram-positive and negative bacteria. Its activity appears to be mediated by its ability to damage bacterial membranes; Belongs to the cathelicidin family.
   
  
 0.692
SPAG11
Uncharacterized protein.
   
  
 0.611
MUC2
Uncharacterized protein.
      
 0.553
DEFB124
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.536
VSIG2
V-set and immunoglobulin domain containing 2.
      
 0.535
MUC1
SEA domain-containing protein.
      
 0.505
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.