STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NRIP1Nuclear receptor-interacting protein 1 isoform X1. (1156 aa)    
Predicted Functional Partners:
ESR1
Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]
    
 0.902
TLE3
TLE family member 3, transcriptional corepressor.
     
 0.865
EP300
E1A binding protein p300.
   
 
 0.833
FOXA1
Forkhead box A1.
     
 0.833
GATA3
Trans-acting T-cell-specific transcription factor GATA-3.
     
 0.818
RORA
RAR related orphan receptor A.
    
 
 0.752
RORC
RAR related orphan receptor C.
    
 
 0.724
PGR
Progesterone receptor isoform B.
    
 0.653
GMEB1
Glucocorticoid modulatory element binding protein 1.
      
 0.606
ESRRB
Estrogen related receptor beta.
    
 
 0.601
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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