node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | CS | ENSSSCP00000018460 | ENSSSCP00000056310 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.995 |
ACLY | FH | ENSSSCP00000018460 | ENSSSCP00000046547 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | 0.709 |
ACLY | GOT1 | ENSSSCP00000018460 | ENSSSCP00000011226 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.853 |
ACLY | GOT2 | ENSSSCP00000018460 | ENSSSCP00000055842 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.855 |
ACLY | MDH1 | ENSSSCP00000018460 | ENSSSCP00000062430 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malate dehydrogenase, cytoplasmic. | 0.972 |
ACLY | MDH2 | ENSSSCP00000018460 | ENSSSCP00000070379 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malate dehydrogenase, mitochondrial. | 0.973 |
ACLY | ME1 | ENSSSCP00000018460 | ENSSSCP00000071155 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | NADP-dependent malic enzyme; Belongs to the malic enzymes family. | 0.766 |
ACLY | ME2 | ENSSSCP00000018460 | ENSSSCP00000033232 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malic enzyme. | 0.561 |
ACLY | ME3 | ENSSSCP00000018460 | ENSSSCP00000015839 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malic enzyme. | 0.481 |
ACLY | PCK2 | ENSSSCP00000018460 | ENSSSCP00000042529 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Phosphoenolpyruvate carboxykinase 2, mitochondrial. | 0.933 |
CS | ACLY | ENSSSCP00000056310 | ENSSSCP00000018460 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.995 |
CS | FH | ENSSSCP00000056310 | ENSSSCP00000046547 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | 0.975 |
CS | GOT1 | ENSSSCP00000056310 | ENSSSCP00000011226 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.892 |
CS | GOT2 | ENSSSCP00000056310 | ENSSSCP00000055842 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.932 |
CS | MDH1 | ENSSSCP00000056310 | ENSSSCP00000062430 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Malate dehydrogenase, cytoplasmic. | 0.995 |
CS | MDH2 | ENSSSCP00000056310 | ENSSSCP00000070379 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Malate dehydrogenase, mitochondrial. | 0.998 |
CS | ME1 | ENSSSCP00000056310 | ENSSSCP00000071155 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | NADP-dependent malic enzyme; Belongs to the malic enzymes family. | 0.964 |
CS | ME2 | ENSSSCP00000056310 | ENSSSCP00000033232 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Malic enzyme. | 0.955 |
CS | ME3 | ENSSSCP00000056310 | ENSSSCP00000015839 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Malic enzyme. | 0.955 |
CS | PCK2 | ENSSSCP00000056310 | ENSSSCP00000042529 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Phosphoenolpyruvate carboxykinase 2, mitochondrial. | 0.943 |