node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B4GALNT2 | CD46 | ENSSSCP00000074222 | ENSSSCP00000043156 | Glyco_trans_2-like domain-containing protein. | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | 0.669 |
B4GALNT2 | CD55 | ENSSSCP00000074222 | ENSSSCP00000033510 | Glyco_trans_2-like domain-containing protein. | Uncharacterized protein. | 0.610 |
B4GALNT2 | CD59 | ENSSSCP00000074222 | ENSSSCP00000025898 | Glyco_trans_2-like domain-containing protein. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. | 0.667 |
B4GALNT2 | CMAH | ENSSSCP00000074222 | ENSSSCP00000060314 | Glyco_trans_2-like domain-containing protein. | Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell- pathogen interactions. Catalyzes the conversion of CMP-N- acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. | 0.921 |
B4GALNT2 | THBD | ENSSSCP00000074222 | ENSSSCP00000060247 | Glyco_trans_2-like domain-containing protein. | Uncharacterized protein. | 0.532 |
C9 | CD59 | ENSSSCP00000017860 | ENSSSCP00000025898 | MACPF domain-containing protein. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. | 0.825 |
CD46 | B4GALNT2 | ENSSSCP00000043156 | ENSSSCP00000074222 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | Glyco_trans_2-like domain-containing protein. | 0.669 |
CD46 | CD55 | ENSSSCP00000043156 | ENSSSCP00000033510 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | Uncharacterized protein. | 0.669 |
CD46 | CD59 | ENSSSCP00000043156 | ENSSSCP00000025898 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. | 0.957 |
CD46 | CMAH | ENSSSCP00000043156 | ENSSSCP00000060314 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell- pathogen interactions. Catalyzes the conversion of CMP-N- acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. | 0.634 |
CD46 | ENTPD1 | ENSSSCP00000043156 | ENSSSCP00000011184 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | Ectonucleoside triphosphate diphosphohydrolase 1 27 kDa subunit; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. | 0.750 |
CD46 | F1S342_PIG | ENSSSCP00000043156 | ENSSSCP00000016221 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | Uncharacterized protein. | 0.902 |
CD46 | SERPING1 | ENSSSCP00000043156 | ENSSSCP00000014011 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. | 0.703 |
CD46 | THBD | ENSSSCP00000043156 | ENSSSCP00000060247 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | Uncharacterized protein. | 0.879 |
CD55 | B4GALNT2 | ENSSSCP00000033510 | ENSSSCP00000074222 | Uncharacterized protein. | Glyco_trans_2-like domain-containing protein. | 0.610 |
CD55 | CD46 | ENSSSCP00000033510 | ENSSSCP00000043156 | Uncharacterized protein. | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. | 0.669 |
CD55 | CD59 | ENSSSCP00000033510 | ENSSSCP00000025898 | Uncharacterized protein. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. | 0.967 |
CD55 | CMAH | ENSSSCP00000033510 | ENSSSCP00000060314 | Uncharacterized protein. | Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell- pathogen interactions. Catalyzes the conversion of CMP-N- acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. | 0.634 |
CD55 | ENTPD1 | ENSSSCP00000033510 | ENSSSCP00000011184 | Uncharacterized protein. | Ectonucleoside triphosphate diphosphohydrolase 1 27 kDa subunit; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. | 0.795 |
CD55 | F1S342_PIG | ENSSSCP00000033510 | ENSSSCP00000016221 | Uncharacterized protein. | Uncharacterized protein. | 0.451 |