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MEF2A protein (Sus scrofa) - STRING interaction network
"MEF2A" - Myocyte-specific enhancer factor 2A in Sus scrofa
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
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MEF2AMyocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylat [...] (425 aa)    
Predicted Functional Partners:
MYOD1
Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) (319 aa)
     
  0.964
MYOG
Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] (224 aa)
     
  0.962
MYF5
Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation (263 aa)
     
  0.956
MEF2B
Myocyte enhancer factor 2B (369 aa)
 
   
  0.953
MAPK14
Mitogen-activated protein kinase 14 (360 aa)
     
  0.947
MYF6
Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity) (242 aa)
     
  0.940
TCF4
Transcription factor 4 (511 aa)
     
  0.930
TCF3
Transcription factor 3 (684 aa)
     
  0.924
CTNNA1
Catenin alpha 1; Catenin (cadherin-associated protein), alpha 1, 102kDa (906 aa)
     
 
  0.919
ENSSSCG00000006482
Uncharacterized protein (522 aa)
     
0.918
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
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