node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHID1 | PSAP | ENSSSCP00000063918 | ENSSSCP00000035634 | Chitinase domain containing 1. | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. | 0.751 |
GALC | GBA | ENSSSCP00000021318 | ENSSSCP00000006950 | Galactocerebrosidase isoform a. | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | 0.949 |
GALC | GNLY | ENSSSCP00000021318 | ENSSSCP00000068499 | Galactocerebrosidase isoform a. | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | 0.543 |
GALC | PSAP | ENSSSCP00000021318 | ENSSSCP00000035634 | Galactocerebrosidase isoform a. | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. | 0.666 |
GALC | PSAPL1 | ENSSSCP00000021318 | ENSSSCP00000009288 | Galactocerebrosidase isoform a. | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. | 0.666 |
GBA | GALC | ENSSSCP00000006950 | ENSSSCP00000021318 | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | Galactocerebrosidase isoform a. | 0.949 |
GBA | LAMP1 | ENSSSCP00000006950 | ENSSSCP00000010202 | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | Uncharacterized protein. | 0.605 |
GBA | PSAP | ENSSSCP00000006950 | ENSSSCP00000035634 | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. | 0.940 |
GNLY | GALC | ENSSSCP00000068499 | ENSSSCP00000021318 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Galactocerebrosidase isoform a. | 0.543 |
GNLY | PSAP | ENSSSCP00000068499 | ENSSSCP00000035634 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. | 0.689 |
GNLY | PSAPL1 | ENSSSCP00000068499 | ENSSSCP00000009288 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. | 0.801 |
GPR37 | GPR37L1 | ENSSSCP00000072321 | ENSSSCP00000036180 | G protein-coupled receptor 37. | G protein-coupled receptor 37 like 1. | 0.578 |
GPR37 | PSAP | ENSSSCP00000072321 | ENSSSCP00000035634 | G protein-coupled receptor 37. | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. | 0.971 |
GPR37L1 | GPR37 | ENSSSCP00000036180 | ENSSSCP00000072321 | G protein-coupled receptor 37 like 1. | G protein-coupled receptor 37. | 0.578 |
GPR37L1 | PSAP | ENSSSCP00000036180 | ENSSSCP00000035634 | G protein-coupled receptor 37 like 1. | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. | 0.987 |
GPR37L1 | SORT1 | ENSSSCP00000036180 | ENSSSCP00000037889 | G protein-coupled receptor 37 like 1. | Sortilin. | 0.400 |
GRN | LAMP1 | ENSSSCP00000071039 | ENSSSCP00000010202 | Uncharacterized protein. | Uncharacterized protein. | 0.653 |
GRN | PSAP | ENSSSCP00000071039 | ENSSSCP00000035634 | Uncharacterized protein. | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. | 0.691 |
GRN | PSAPL1 | ENSSSCP00000071039 | ENSSSCP00000009288 | Uncharacterized protein. | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. | 0.448 |
GRN | SORT1 | ENSSSCP00000071039 | ENSSSCP00000037889 | Uncharacterized protein. | Sortilin. | 0.759 |