node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP5B1 | NPG1 | ENSSSCP00000013800 | ENSSSCP00000042895 | Adaptor related protein complex 5 subunit beta 1. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.512 |
DEFB1 | DEFB1-2 | ENSSSCP00000024082 | ENSSSCP00000025388 | Beta-defensin 1. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. | 0.991 |
DEFB1 | NPG1 | ENSSSCP00000024082 | ENSSSCP00000042895 | Beta-defensin 1. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.864 |
DEFB1-2 | DEFB1 | ENSSSCP00000025388 | ENSSSCP00000024082 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. | Beta-defensin 1. | 0.991 |
DEFB1-2 | NPG1 | ENSSSCP00000025388 | ENSSSCP00000042895 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.772 |
DRC1 | DRC3 | ENSSSCP00000009134 | ENSSSCP00000041364 | Dynein regulatory complex subunit 1. | Dynein regulatory complex subunit 3. | 0.924 |
DRC1 | NPG1 | ENSSSCP00000009134 | ENSSSCP00000042895 | Dynein regulatory complex subunit 1. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.557 |
DRC3 | DRC1 | ENSSSCP00000041364 | ENSSSCP00000009134 | Dynein regulatory complex subunit 3. | Dynein regulatory complex subunit 1. | 0.924 |
DRC3 | NPG1 | ENSSSCP00000041364 | ENSSSCP00000042895 | Dynein regulatory complex subunit 3. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.604 |
ELANE | LTF | ENSSSCP00000024494 | ENSSSCP00000026769 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. | 0.743 |
ELANE | NPG1 | ENSSSCP00000024494 | ENSSSCP00000042895 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.554 |
HLA-DRA | NPG1 | ENSSSCP00000001567 | ENSSSCP00000042895 | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.603 |
LOC100736951 | NPG1 | ENSSSCP00000012087 | ENSSSCP00000042895 | Uncharacterized protein. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.786 |
LTF | ELANE | ENSSSCP00000026769 | ENSSSCP00000024494 | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | 0.743 |
LTF | NPG1 | ENSSSCP00000026769 | ENSSSCP00000042895 | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | 0.800 |
LTF | PGLYRP1 | ENSSSCP00000026769 | ENSSSCP00000031294 | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. | 20 kDa neutrophil cationic protein. | 0.775 |
NPG1 | AP5B1 | ENSSSCP00000042895 | ENSSSCP00000013800 | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | Adaptor related protein complex 5 subunit beta 1. | 0.512 |
NPG1 | DEFB1 | ENSSSCP00000042895 | ENSSSCP00000024082 | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | Beta-defensin 1. | 0.864 |
NPG1 | DEFB1-2 | ENSSSCP00000042895 | ENSSSCP00000025388 | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. | 0.772 |
NPG1 | DRC1 | ENSSSCP00000042895 | ENSSSCP00000009134 | Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family. | Dynein regulatory complex subunit 1. | 0.557 |