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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HNF1BHepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the PFC element in the UPA gene. (577 aa)    
Predicted Functional Partners:
PCBD1
Pterin-4 alpha-carbinolamine dehydratase 1.
    
 
 0.812
PDX1
Homeobox domain-containing protein.
   
  
 0.706
CTRC
Chymotrypsin-C; Belongs to the peptidase S1 family.
   
  
 0.670
HNF4A
Hepatocyte nuclear factor 4 alpha.
   
 
 0.661
PCBD2
Uncharacterized protein.
    
 
 0.618
GATA6
Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.
   
  
 0.548
TMEM65
Transmembrane protein 65.
      
 0.540
RBPJL
Recombination signal binding protein for immunoglobulin kappa J region like.
      
 0.526
BHLHA15
Basic helix-loop-helix family member a15.
      
 0.524
FOXA3
Forkhead box A3.
   
  
 0.521
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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