EGF protein (Sus scrofa) - STRING interaction network

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EGF

Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)

Predicted Functional Partners:

EGFR

0.999

ERBB2

0.997

INS

0.996

ERBB3

0.989

ERBB4

0.984

IGF1

0.980

TGFA

0.979

INSR

0.975

IGF1R

0.963

HGF

0.962

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGF	EGFR	ENSSSCP00000028117	ENSSSCP00000068369	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Receptor protein-tyrosine kinase.	0.999
EGF	ERBB2	ENSSSCP00000028117	ENSSSCP00000018545	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Receptor protein-tyrosine kinase.	0.997
EGF	ERBB3	ENSSSCP00000028117	ENSSSCP00000019799	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Erb-b2 receptor tyrosine kinase 3.	0.989
EGF	ERBB4	ENSSSCP00000028117	ENSSSCP00000017120	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Receptor protein-tyrosine kinase.	0.984
EGF	HGF	ENSSSCP00000028117	ENSSSCP00000016330	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.962
EGF	IGF1	ENSSSCP00000028117	ENSSSCP00000000915	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.980
EGF	IGF1R	ENSSSCP00000028117	ENSSSCP00000005181	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Tyrosine-protein kinase receptor.	0.963
EGF	INS	ENSSSCP00000028117	ENSSSCP00000044635	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.996
EGF	INSR	ENSSSCP00000028117	ENSSSCP00000014414	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Tyrosine-protein kinase receptor.	0.975
EGF	TGFA	ENSSSCP00000028117	ENSSSCP00000008889	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.	0.979
EGFR	EGF	ENSSSCP00000068369	ENSSSCP00000028117	Receptor protein-tyrosine kinase.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	0.999
EGFR	ERBB2	ENSSSCP00000068369	ENSSSCP00000018545	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.997
EGFR	ERBB3	ENSSSCP00000068369	ENSSSCP00000019799	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.987
EGFR	ERBB4	ENSSSCP00000068369	ENSSSCP00000017120	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.949
EGFR	HGF	ENSSSCP00000068369	ENSSSCP00000016330	Receptor protein-tyrosine kinase.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.937
EGFR	IGF1	ENSSSCP00000068369	ENSSSCP00000000915	Receptor protein-tyrosine kinase.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.965
EGFR	IGF1R	ENSSSCP00000068369	ENSSSCP00000005181	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.962
EGFR	INS	ENSSSCP00000068369	ENSSSCP00000044635	Receptor protein-tyrosine kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.980
EGFR	INSR	ENSSSCP00000068369	ENSSSCP00000014414	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.850
EGFR	TGFA	ENSSSCP00000068369	ENSSSCP00000008889	Receptor protein-tyrosine kinase.	Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.	0.999

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