STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACEAngiotensin-converting enzyme. (1309 aa)    
Predicted Functional Partners:
REN
Renin preproprotein; Belongs to the peptidase A1 family.
     
 0.993
AGT
Angiotensinogen; Belongs to the serpin family.
    
 0.992
MME
Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family.
   
 
 0.987
ENPEP
Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II; Belongs to the peptidase M1 family.
   
 0.964
KNG1
Kininogen 1.
    
 0.959
ACE2
Angiotensin-converting enzyme.
  
 
0.957
THOP1
Thimet oligopeptidase; Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation; Belongs to the peptidase M3 family.
     
 0.956
NLN
Neurolysin, mitochondrial; Binds angiotensins and its analogs; Belongs to the peptidase M3 family.
     
 0.952
PRCP
Prolylcarboxypeptidase.
     
 0.945
CTSA
Carboxypeptidase; Belongs to the peptidase S10 family.
     
 0.934
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.