SPIN1 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SPIN1

Uncharacterized protein. (272 aa)

Predicted Functional Partners:

GALNT6

0.770

FOXQ1

0.764

BIN2

0.725

LHFPL3

0.684

HUS1

0.669

CELA1

0.610

SPINDOC

0.598

HTATSF1

0.499

GGH

0.489

MYOZ1

0.475

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIN2	CELA1	ENSSSCP00000020147	ENSSSCP00000064311	Bridging integrator 2.	Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	0.622
BIN2	GALNT6	ENSSSCP00000020147	ENSSSCP00000039780	Bridging integrator 2.	Polypeptide N-acetylgalactosaminyltransferase.	0.608
BIN2	SPIN1	ENSSSCP00000020147	ENSSSCP00000032404	Bridging integrator 2.	Uncharacterized protein.	0.725
CELA1	BIN2	ENSSSCP00000064311	ENSSSCP00000020147	Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	Bridging integrator 2.	0.622
CELA1	GALNT6	ENSSSCP00000064311	ENSSSCP00000039780	Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	Polypeptide N-acetylgalactosaminyltransferase.	0.699
CELA1	SPIN1	ENSSSCP00000064311	ENSSSCP00000032404	Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	Uncharacterized protein.	0.610
FOXQ1	LHFPL3	ENSSSCP00000001059	ENSSSCP00000035501	Forkhead box Q1.	LHFPL tetraspan subfamily member 3.	0.426
FOXQ1	SPIN1	ENSSSCP00000001059	ENSSSCP00000032404	Forkhead box Q1.	Uncharacterized protein.	0.764
GALNT6	BIN2	ENSSSCP00000039780	ENSSSCP00000020147	Polypeptide N-acetylgalactosaminyltransferase.	Bridging integrator 2.	0.608
GALNT6	CELA1	ENSSSCP00000039780	ENSSSCP00000064311	Polypeptide N-acetylgalactosaminyltransferase.	Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	0.699
GALNT6	SPIN1	ENSSSCP00000039780	ENSSSCP00000032404	Polypeptide N-acetylgalactosaminyltransferase.	Uncharacterized protein.	0.770
GGH	SPIN1	ENSSSCP00000006638	ENSSSCP00000032404	Folate gamma-glutamyl hydrolase.	Uncharacterized protein.	0.489
HTATSF1	SPIN1	ENSSSCP00000021619	ENSSSCP00000032404	HIV-1 Tat specific factor 1.	Uncharacterized protein.	0.499
HUS1	SPIN1	ENSSSCP00000040283	ENSSSCP00000032404	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.669
LHFPL3	FOXQ1	ENSSSCP00000035501	ENSSSCP00000001059	LHFPL tetraspan subfamily member 3.	Forkhead box Q1.	0.426
LHFPL3	SPIN1	ENSSSCP00000035501	ENSSSCP00000032404	LHFPL tetraspan subfamily member 3.	Uncharacterized protein.	0.684
MYOZ1	SPIN1	ENSSSCP00000010985	ENSSSCP00000032404	Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity).	Uncharacterized protein.	0.475
SPIN1	BIN2	ENSSSCP00000032404	ENSSSCP00000020147	Uncharacterized protein.	Bridging integrator 2.	0.725
SPIN1	CELA1	ENSSSCP00000032404	ENSSSCP00000064311	Uncharacterized protein.	Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	0.610
SPIN1	FOXQ1	ENSSSCP00000032404	ENSSSCP00000001059	Uncharacterized protein.	Forkhead box Q1.	0.764

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

16

average node degree:

2.91

avg. local clustering coefficient:

0.861

expected number of edges:

12

PPI enrichment p-value:

0.164

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070286

Axonemal dynein complex assembly

6 of 32

2.55

5.21

6.00e-11

GO:0003341

Cilium movement

7 of 143

1.97

3.85

7.51e-10

GO:0007018

Microtubule-based movement

9 of 337

1.71

3.45

4.91e-11

GO:0044782

Cilium organization

8 of 320

1.68

3.08

1.17e-09

GO:0007017

Microtubule-based process

10 of 725

1.42

2.48

1.06e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045503

Dynein light chain binding

4 of 9

2.93

3.83

8.86e-08

GO:0045504

Dynein heavy chain binding

4 of 13

2.77

3.67

1.47e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005858

Axonemal dynein complex

4 of 15

2.7

3.77

8.49e-08

GO:0030286

Dynein complex

5 of 57

2.22

3.46

8.49e-08

GO:0005875

Microtubule associated complex

6 of 144

1.9

3.05

8.49e-08

GO:0032838

Plasma membrane bounded cell projection cytoplasm

6 of 201

1.75

2.73

1.49e-07

GO:0005930

Axoneme

5 of 140

1.83

2.54

1.47e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33101214

(2020) The Role of Genetics and Oxidative Stress in the Etiology of Male Infertility-A Unifying Hypothesis?

8 of 70

2.34

5.89

2.82e-13

PMID:34768622

(2021) A Study on the Genetics of Primary Ciliary Dyskinesia.

4 of 16

2.68

2.79

6.67e-06

PMID:36714566

(2022) Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization.

3 of 27

2.32

1.09

0.0097

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17689

Mixed, incl. Dynein complex, and Dynactin complex

8 of 118

2.11

5.13

1.04e-12

CL:17827

Mixed, incl. Axonemal dynein complex assembly, and Dynein heavy chain 3, AAA+ lid domain

6 of 42

2.43

4.96

1.12e-10

CL:17830

Axonemal dynein complex assembly, and Dynein heavy chain, tail

4 of 20

2.58

3.33

5.05e-07

CL:17831

Axonemal dynein complex assembly, and Radial spokehead-like protein

3 of 13

2.64

2.34

4.65e-05

CL:17833

Mixed, incl. Outer dynein arm, and Sperm tail

2 of 7

2.73

1.22

0.0060

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001363

Testis

7 of 793

1.22

1.33

3.48e-05

BTO:0000082

Male reproductive system

8 of 1145

1.12

1.2

2.45e-05

BTO:0000522

Gland

8 of 4071

0.57

0.35

0.0402

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005858

Axonemal dynein complex

5 of 19

2.7

4.73

1.06e-09

GOCC:0005930

Axoneme

6 of 101

2.05

3.7

6.37e-09

GOCC:0005875

Microtubule associated complex

6 of 112

2.01

3.62

6.37e-09

GOCC:0005929

Cilium

7 of 422

1.5

2.26

1.01e-07

GOCC:0036156

Inner dynein arm

2 of 6

2.8

1.65

0.00098

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

4 of 271

1.45

0.95

0.0073

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