STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPHA6EPH receptor A6. (1153 aa)    
Predicted Functional Partners:
ABL1
Tyrosine-protein kinase.
   
0.926
EFNA5
Ephrin A5; Belongs to the ephrin family.
   
 0.915
NGEF
Neuronal guanine nucleotide exchange factor.
    
 0.911
RASA1
RAS p21 protein activator 1.
   
 0.911
EFNA2
Ephrin A2; Belongs to the ephrin family.
   
 0.878
EFNA1
Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]
   
 0.863
EFNA4
Ephrin A4; Belongs to the ephrin family.
   
 0.854
EFNA3
Ephrin RBD domain-containing protein; Belongs to the ephrin family.
   
 0.853
EFNB2
Ephrin RBD domain-containing protein; Belongs to the ephrin family.
   
 0.741
EFNB3
Ephrin-B3; Belongs to the ephrin family.
   
 0.737
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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