node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABL1 | EPHA6 | ENSSSCP00000053721 | ENSSSCP00000032586 | Tyrosine-protein kinase. | EPH receptor A6. | 0.926 |
EFNA1 | EFNA2 | ENSSSCP00000006959 | ENSSSCP00000045529 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin A2; Belongs to the ephrin family. | 0.482 |
EFNA1 | EFNA3 | ENSSSCP00000006959 | ENSSSCP00000006960 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.547 |
EFNA1 | EFNA4 | ENSSSCP00000006959 | ENSSSCP00000035887 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin A4; Belongs to the ephrin family. | 0.510 |
EFNA1 | EFNA5 | ENSSSCP00000006959 | ENSSSCP00000034604 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin A5; Belongs to the ephrin family. | 0.560 |
EFNA1 | EFNB2 | ENSSSCP00000006959 | ENSSSCP00000037283 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.644 |
EFNA1 | EFNB3 | ENSSSCP00000006959 | ENSSSCP00000019014 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin-B3; Belongs to the ephrin family. | 0.627 |
EFNA1 | EPHA6 | ENSSSCP00000006959 | ENSSSCP00000032586 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | EPH receptor A6. | 0.863 |
EFNA1 | RASA1 | ENSSSCP00000006959 | ENSSSCP00000060406 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | RAS p21 protein activator 1. | 0.912 |
EFNA2 | EFNA1 | ENSSSCP00000045529 | ENSSSCP00000006959 | Ephrin A2; Belongs to the ephrin family. | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | 0.482 |
EFNA2 | EFNA3 | ENSSSCP00000045529 | ENSSSCP00000006960 | Ephrin A2; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.412 |
EFNA2 | EFNA4 | ENSSSCP00000045529 | ENSSSCP00000035887 | Ephrin A2; Belongs to the ephrin family. | Ephrin A4; Belongs to the ephrin family. | 0.419 |
EFNA2 | EFNA5 | ENSSSCP00000045529 | ENSSSCP00000034604 | Ephrin A2; Belongs to the ephrin family. | Ephrin A5; Belongs to the ephrin family. | 0.548 |
EFNA2 | EFNB2 | ENSSSCP00000045529 | ENSSSCP00000037283 | Ephrin A2; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.621 |
EFNA2 | EFNB3 | ENSSSCP00000045529 | ENSSSCP00000019014 | Ephrin A2; Belongs to the ephrin family. | Ephrin-B3; Belongs to the ephrin family. | 0.635 |
EFNA2 | EPHA6 | ENSSSCP00000045529 | ENSSSCP00000032586 | Ephrin A2; Belongs to the ephrin family. | EPH receptor A6. | 0.878 |
EFNA2 | RASA1 | ENSSSCP00000045529 | ENSSSCP00000060406 | Ephrin A2; Belongs to the ephrin family. | RAS p21 protein activator 1. | 0.900 |
EFNA3 | EFNA1 | ENSSSCP00000006960 | ENSSSCP00000006959 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | 0.547 |
EFNA3 | EFNA2 | ENSSSCP00000006960 | ENSSSCP00000045529 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin A2; Belongs to the ephrin family. | 0.412 |
EFNA3 | EFNA4 | ENSSSCP00000006960 | ENSSSCP00000035887 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin A4; Belongs to the ephrin family. | 0.461 |