STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HKDC1Hexokinase domain containing 1. (917 aa)    
Predicted Functional Partners:
GPI
Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
 
 
 
 0.988
PFKM
ATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
   
 
 0.985
PFKL
6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
   
 
 0.974
TIGAR
TP53 induced glycolysis regulatory phosphatase.
   
 0.958
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3.
   
 0.955
FBP2
FBPase domain-containing protein; Belongs to the FBPase class 1 family.
   
 
 0.955
G6PC
Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.
   
 
 0.951
G6PC3
Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.
   
 
 0.947
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1.
   
 0.945
PFKFB2
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1.
   
 0.944
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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