node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARRB1 | OR56B4 | ENSSSCP00000033134 | ENSSSCP00000033847 | Arrestin beta 1. | Olfactory receptor family 56 subfamily B member 4. | 0.650 |
ARRB1 | PRKACA | ENSSSCP00000033134 | ENSSSCP00000035101 | Arrestin beta 1. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.603 |
ARRB1 | PRKACB | ENSSSCP00000033134 | ENSSSCP00000058922 | Arrestin beta 1. | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] | 0.603 |
CNGA4 | GNAL | ENSSSCP00000015560 | ENSSSCP00000026869 | Cyclic nucleotide gated channel subunit alpha 4. | G protein subunit alpha L. | 0.666 |
CNGA4 | GNG13 | ENSSSCP00000015560 | ENSSSCP00000008555 | Cyclic nucleotide gated channel subunit alpha 4. | G protein subunit gamma 13. | 0.562 |
CNGA4 | GPR171 | ENSSSCP00000015560 | ENSSSCP00000067238 | Cyclic nucleotide gated channel subunit alpha 4. | Putative G-protein coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. | 0.574 |
CNGA4 | GPR87 | ENSSSCP00000015560 | ENSSSCP00000045397 | Cyclic nucleotide gated channel subunit alpha 4. | G-protein coupled receptor 87; Belongs to the G-protein coupled receptor 1 family. | 0.720 |
CNGA4 | OR56B4 | ENSSSCP00000015560 | ENSSSCP00000033847 | Cyclic nucleotide gated channel subunit alpha 4. | Olfactory receptor family 56 subfamily B member 4. | 0.752 |
CNGA4 | P2RY14 | ENSSSCP00000015560 | ENSSSCP00000053294 | Cyclic nucleotide gated channel subunit alpha 4. | Purinergic receptor P2Y14. | 0.563 |
GNAL | CNGA4 | ENSSSCP00000026869 | ENSSSCP00000015560 | G protein subunit alpha L. | Cyclic nucleotide gated channel subunit alpha 4. | 0.666 |
GNAL | GNB1 | ENSSSCP00000026869 | ENSSSCP00000048402 | G protein subunit alpha L. | G protein subunit beta 1. | 0.976 |
GNAL | GNG13 | ENSSSCP00000026869 | ENSSSCP00000008555 | G protein subunit alpha L. | G protein subunit gamma 13. | 0.975 |
GNAL | OR56B4 | ENSSSCP00000026869 | ENSSSCP00000033847 | G protein subunit alpha L. | Olfactory receptor family 56 subfamily B member 4. | 0.658 |
GNB1 | GNAL | ENSSSCP00000048402 | ENSSSCP00000026869 | G protein subunit beta 1. | G protein subunit alpha L. | 0.976 |
GNB1 | GNG13 | ENSSSCP00000048402 | ENSSSCP00000008555 | G protein subunit beta 1. | G protein subunit gamma 13. | 0.959 |
GNB1 | OR56B4 | ENSSSCP00000048402 | ENSSSCP00000033847 | G protein subunit beta 1. | Olfactory receptor family 56 subfamily B member 4. | 0.650 |
GNB1 | PRKACA | ENSSSCP00000048402 | ENSSSCP00000035101 | G protein subunit beta 1. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.720 |
GNB1 | PRKACB | ENSSSCP00000048402 | ENSSSCP00000058922 | G protein subunit beta 1. | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] | 0.720 |
GNG13 | CNGA4 | ENSSSCP00000008555 | ENSSSCP00000015560 | G protein subunit gamma 13. | Cyclic nucleotide gated channel subunit alpha 4. | 0.562 |
GNG13 | GNAL | ENSSSCP00000008555 | ENSSSCP00000026869 | G protein subunit gamma 13. | G protein subunit alpha L. | 0.975 |