STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARL4CUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (192 aa)    
Predicted Functional Partners:
TRIP11
Thyroid hormone receptor interactor 11.
   
 
 0.794
METTL11B
Methyltransferase like 11B.
      
 0.762
DIS3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family.
    
 
 0.694
WDTC1
WD and tetratricopeptide repeats 1.
    
 
 0.689
ITSN2
Intersectin 2.
    
 
 0.637
ITSN1
Intersectin 1.
    
 
 0.604
SPP2
Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover; Belongs to the SPP2 family.
      
 0.592
OPRD1
Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. [...]
    
 
 0.560
RIBC1
RIB43A domain with coiled-coils 1.
   
 
 0.558
NGEF
Neuronal guanine nucleotide exchange factor.
    
 
 0.551
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.