SH3PXD2A protein (Sus scrofa) - STRING interaction network

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Score

SH3PXD2A

SH3 and PX domain-containing protein 2A. (1133 aa)

Predicted Functional Partners:

FAM13B

0.804

FRMD8

0.747

ADAM12

0.684

ADAM15

0.665

CDC42

0.664

CYFIP2

0.637

ADAM19

0.587

WASL

0.539

NEK6

0.534

FBXW7

0.530

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM12	SH3PXD2A	ENSSSCP00000043168	ENSSSCP00000036094	ADAM metallopeptidase domain 12.	SH3 and PX domain-containing protein 2A.	0.684
ADAM15	SH3PXD2A	ENSSSCP00000006962	ENSSSCP00000036094	Disintegrin and metalloproteinase domain-containing protein 15 isoform 6 preproprotein.	SH3 and PX domain-containing protein 2A.	0.665
ADAM19	SH3PXD2A	ENSSSCP00000018065	ENSSSCP00000036094	ADAM metallopeptidase domain 19.	SH3 and PX domain-containing protein 2A.	0.587
CDC42	CYFIP2	ENSSSCP00000029815	ENSSSCP00000048040	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.615
CDC42	FAM13B	ENSSSCP00000029815	ENSSSCP00000048664	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Family with sequence similarity 13 member B.	0.446
CDC42	SH3PXD2A	ENSSSCP00000029815	ENSSSCP00000036094	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	SH3 and PX domain-containing protein 2A.	0.664
CDC42	WASL	ENSSSCP00000029815	ENSSSCP00000061208	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	WASP like actin nucleation promoting factor.	0.997
CYFIP2	CDC42	ENSSSCP00000048040	ENSSSCP00000029815	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.615
CYFIP2	FAM13B	ENSSSCP00000048040	ENSSSCP00000048664	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	Family with sequence similarity 13 member B.	0.763
CYFIP2	SH3PXD2A	ENSSSCP00000048040	ENSSSCP00000036094	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	SH3 and PX domain-containing protein 2A.	0.637
CYFIP2	WASL	ENSSSCP00000048040	ENSSSCP00000061208	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	WASP like actin nucleation promoting factor.	0.626
FAM13B	CDC42	ENSSSCP00000048664	ENSSSCP00000029815	Family with sequence similarity 13 member B.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.446
FAM13B	CYFIP2	ENSSSCP00000048664	ENSSSCP00000048040	Family with sequence similarity 13 member B.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.763
FAM13B	FBXW7	ENSSSCP00000048664	ENSSSCP00000022261	Family with sequence similarity 13 member B.	F-box and WD repeat domain containing 7.	0.583
FAM13B	SH3PXD2A	ENSSSCP00000048664	ENSSSCP00000036094	Family with sequence similarity 13 member B.	SH3 and PX domain-containing protein 2A.	0.804
FBXW7	FAM13B	ENSSSCP00000022261	ENSSSCP00000048664	F-box and WD repeat domain containing 7.	Family with sequence similarity 13 member B.	0.583
FBXW7	SH3PXD2A	ENSSSCP00000022261	ENSSSCP00000036094	F-box and WD repeat domain containing 7.	SH3 and PX domain-containing protein 2A.	0.530
FRMD8	NEK6	ENSSSCP00000062837	ENSSSCP00000035820	FERM domain containing 8.	Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase- anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence [...]	0.613
FRMD8	SH3PXD2A	ENSSSCP00000062837	ENSSSCP00000036094	FERM domain containing 8.	SH3 and PX domain-containing protein 2A.	0.747
NEK6	FRMD8	ENSSSCP00000035820	ENSSSCP00000062837	Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase- anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence [...]	FERM domain containing 8.	0.613