LOC100516039 protein (Sus scrofa) - STRING interaction network

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Score

LOC100516039

C-C motif chemokine. (243 aa)

Predicted Functional Partners:

CCR1

0.974

CCL24

0.938

CCL5

0.932

CCL11

0.926

CCL27

0.913

CCL26

0.910

CCL28

0.909

CCR4

0.842

CCL2

0.827

CCL21

0.785

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL11	CCL2	ENSSSCP00000018778	ENSSSCP00000018779	C-C motif chemokine.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.866
CCL11	CCL24	ENSSSCP00000018778	ENSSSCP00000032478	C-C motif chemokine.	SCY domain-containing protein.	0.909
CCL11	CCL26	ENSSSCP00000018778	ENSSSCP00000057456	C-C motif chemokine.	C-C motif chemokine.	0.970
CCL11	CCL27	ENSSSCP00000018778	ENSSSCP00000011696	C-C motif chemokine.	C-C motif chemokine 27.	0.976
CCL11	CCL28	ENSSSCP00000018778	ENSSSCP00000017879	C-C motif chemokine.	C-C motif chemokine.	0.968
CCL11	CCL5	ENSSSCP00000018778	ENSSSCP00000028561	C-C motif chemokine.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.971
CCL11	CCR1	ENSSSCP00000018778	ENSSSCP00000012073	C-C motif chemokine.	Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.925
CCL11	CCR4	ENSSSCP00000018778	ENSSSCP00000033921	C-C motif chemokine.	C-C chemokine receptor type 4 isoform X1; Belongs to the G-protein coupled receptor 1 family.	0.783
CCL11	LOC100516039	ENSSSCP00000018778	ENSSSCP00000036324	C-C motif chemokine.	C-C motif chemokine.	0.926
CCL2	CCL11	ENSSSCP00000018779	ENSSSCP00000018778	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine.	0.866
CCL2	CCL21	ENSSSCP00000018779	ENSSSCP00000036350	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Putative CCL21 chemokine.	0.674
CCL2	CCL26	ENSSSCP00000018779	ENSSSCP00000057456	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine.	0.984
CCL2	CCL27	ENSSSCP00000018779	ENSSSCP00000011696	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine 27.	0.953
CCL2	CCL5	ENSSSCP00000018779	ENSSSCP00000028561	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.991
CCL2	CCR1	ENSSSCP00000018779	ENSSSCP00000012073	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.943
CCL2	CCR4	ENSSSCP00000018779	ENSSSCP00000033921	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C chemokine receptor type 4 isoform X1; Belongs to the G-protein coupled receptor 1 family.	0.781
CCL2	LOC100516039	ENSSSCP00000018779	ENSSSCP00000036324	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine.	0.827
CCL21	CCL2	ENSSSCP00000036350	ENSSSCP00000018779	Putative CCL21 chemokine.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.674
CCL21	CCL24	ENSSSCP00000036350	ENSSSCP00000032478	Putative CCL21 chemokine.	SCY domain-containing protein.	0.977
CCL21	CCL26	ENSSSCP00000036350	ENSSSCP00000057456	Putative CCL21 chemokine.	C-C motif chemokine.	0.971