STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)    
Predicted Functional Partners:
SLX4
SLX4 structure-specific endonuclease subunit.
   
 0.991
MUS81
MUS81 structure-specific endonuclease subunit.
   
 0.977
RMI1
RecQ mediated genome instability 1.
    
 0.932
FAAP24
FA core complex associated protein 24.
   
 
 0.926
ARPC4
Actin related protein 2/3 complex subunit 4.
    
 
 0.926
RMI2
RecQ-mediated genome instability protein 2.
     
 0.916
BLM
BLM RecQ like helicase.
    
 0.910
EME1
Essential meiotic structure-specific endonuclease 1.
    
 0.897
WRN
WRN RecQ like helicase.
    
 0.884
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit.
   
 
 0.870
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.