STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZC3HAV1Zinc finger CCCH-type antiviral protein 1 isoform 1. (894 aa)    
Predicted Functional Partners:
CD2BP2
CD2 cytoplasmic tail binding protein 2.
      
 0.577
PRRC2B
Proline rich coiled-coil 2B.
   
 
 0.571
KHNYN
KH and NYN domain containing.
    
 
 0.556
IER5L
Immediate early response 5 like.
      
 0.548
USP18
USP domain-containing protein; Belongs to the peptidase C19 family.
   
 
 0.526
DDX58
Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]
   
 
 0.517
TRIM25
Tripartite motif containing 25.
   
 
 0.504
ZNF106
Zinc finger protein 106.
    
 
 0.499
SH3BP5
SH3 domain binding protein 5.
      
 0.497
RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2 isoform 1.
      
 0.496
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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