STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GIPC3GIPC PDZ domain containing family member 3. (314 aa)    
Predicted Functional Partners:
MYO6
Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). [...]
    
 
 0.810
USH1C
USH1 protein network component harmonin.
   
  
 0.797
ESPN
Espin.
      
 0.758
APPL2
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.
   
 
 0.714
APPL1
Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1.
   
 
 0.714
FILIP1
Filamin-A-interacting protein 1 isoform X1.
      
 0.695
THRB
Thyroid hormone receptor beta isoform X2.
      
 0.649
CEACAM16
Carcinoembryonic antigen related cell adhesion molecule 16.
      
 0.633
BRCA2
Tower domain-containing protein.
      
 0.614
SEMA3E
Semaphorin-3E isoform 1; Belongs to the semaphorin family.
    
 
 0.595
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.