node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ITM2C | METTL21C | ENSSSCP00000017233 | ENSSSCP00000050520 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Methyltransferase like 21C. | 0.663 |
ITM2C | MYH13 | ENSSSCP00000017233 | ENSSSCP00000019076 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Myosin heavy chain 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.551 |
ITM2C | PARM1 | ENSSSCP00000017233 | ENSSSCP00000009568 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Uncharacterized protein. | 0.629 |
ITM2C | SLC35A5 | ENSSSCP00000017233 | ENSSSCP00000038810 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Solute carrier family 35 member A5. | 0.855 |
ITM2C | SPATA6L | ENSSSCP00000017233 | ENSSSCP00000044580 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Spermatogenesis associated 6 like. | 0.541 |
ITM2C | TTLL5 | ENSSSCP00000017233 | ENSSSCP00000030573 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Tubulin tyrosine ligase like 5. | 0.532 |
METTL21C | ITM2C | ENSSSCP00000050520 | ENSSSCP00000017233 | Methyltransferase like 21C. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | 0.663 |
METTL21C | MYH13 | ENSSSCP00000050520 | ENSSSCP00000019076 | Methyltransferase like 21C. | Myosin heavy chain 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.654 |
METTL21C | PARM1 | ENSSSCP00000050520 | ENSSSCP00000009568 | Methyltransferase like 21C. | Uncharacterized protein. | 0.563 |
METTL21C | SLC35A5 | ENSSSCP00000050520 | ENSSSCP00000038810 | Methyltransferase like 21C. | Solute carrier family 35 member A5. | 0.673 |
METTL21C | SPATA6L | ENSSSCP00000050520 | ENSSSCP00000044580 | Methyltransferase like 21C. | Spermatogenesis associated 6 like. | 0.477 |
MYH13 | ITM2C | ENSSSCP00000019076 | ENSSSCP00000017233 | Myosin heavy chain 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | 0.551 |
MYH13 | METTL21C | ENSSSCP00000019076 | ENSSSCP00000050520 | Myosin heavy chain 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Methyltransferase like 21C. | 0.654 |
MYH13 | SLC35A5 | ENSSSCP00000019076 | ENSSSCP00000038810 | Myosin heavy chain 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Solute carrier family 35 member A5. | 0.547 |
PARM1 | ITM2C | ENSSSCP00000009568 | ENSSSCP00000017233 | Uncharacterized protein. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | 0.629 |
PARM1 | METTL21C | ENSSSCP00000009568 | ENSSSCP00000050520 | Uncharacterized protein. | Methyltransferase like 21C. | 0.563 |
PARM1 | SLC35A5 | ENSSSCP00000009568 | ENSSSCP00000038810 | Uncharacterized protein. | Solute carrier family 35 member A5. | 0.627 |
SLC35A5 | ITM2C | ENSSSCP00000038810 | ENSSSCP00000017233 | Solute carrier family 35 member A5. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | 0.855 |
SLC35A5 | METTL21C | ENSSSCP00000038810 | ENSSSCP00000050520 | Solute carrier family 35 member A5. | Methyltransferase like 21C. | 0.673 |
SLC35A5 | MYH13 | ENSSSCP00000038810 | ENSSSCP00000019076 | Solute carrier family 35 member A5. | Myosin heavy chain 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.547 |