STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYP8B15-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 5 beta-cholestane-3-alpha,7-alpha-diol into 5 beta- cholestane-3-alpha,7-alpha,12-alpha triol. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent. (501 aa)    
Predicted Functional Partners:
HSD3B7
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7.
   
 0.967
AKR1D1
3-oxo-5-beta-steroid 4-dehydrogenase isoform 1.
   
 
 0.951
CH25H
Cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25- hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory eleme [...]
   
 0.775
LSS
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
   
 0.774
BAAT
Bile acid-CoA:amino acid N-acyltransferase.
   
  
 0.697
FDFT1
Farnesyl-diphosphate farnesyltransferase 1.
  
 
 0.695
SQLE
Squalene monooxygenase.
   
 0.692
MSMO1
Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family.
   
 0.689
FAXDC2
Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family.
   
 0.689
SLC51B
Organic solute transporter subunit beta.
   
  
 0.684
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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