STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALPK3Alpha-type protein kinase domain-containing protein. (229 aa)    
Predicted Functional Partners:
OBSL1
Obscurin-like protein 1 isoform X2.
   
  
 0.827
CCDC174
Uncharacterized protein.
   
  
 0.789
ATP8B2
Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
      
 0.787
PKD1L2
Uncharacterized protein.
      
 0.763
BOD1L1
Biorientation of chromosomes in cell division protein 1-like 1.
      
 0.681
PLAG1
PLAG1 zinc finger.
      
 0.673
TMEM150A
Transmembrane protein 150A.
      
 0.665
SLC25A44
Solute carrier family 25 member 44; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.665
MED12
Mediator complex subunit 12.
    
 
 0.660
GRB10
Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...]
   
 
 0.658
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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