STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BEST4Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (504 aa)    
Predicted Functional Partners:
RPE65
Retinoid isomerohydrolase RPE65.
      
 0.930
LRAT
Lecithin retinol acyltransferase.
      
 0.670
LRRC8D
Leucine rich repeat containing 8 VRAC subunit D.
      
 0.605
MERTK
MER proto-oncogene, tyrosine kinase.
      
 0.586
LRRC8B
Leucine rich repeat containing 8 VRAC subunit B.
      
 0.559
LRRC8A
Leucine rich repeat containing 8 VRAC subunit A.
      
 0.544
RPGR
Uncharacterized protein.
      
 0.532
OTOP2
Otopetrin 2.
      
 0.520
RLBP1
Retinaldehyde binding protein 1.
   
  
 0.520
GLUL
Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...]
    
 
 0.507
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.