node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKR1C1 | CBR1 | ENSSSCP00000042336 | ENSSSCP00000052333 | Aldo-keto reductase family 1 member C3 isoform 2. | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity). | 0.943 |
AKR1C1 | CYP17A1 | ENSSSCP00000042336 | ENSSSCP00000011283 | Aldo-keto reductase family 1 member C3 isoform 2. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.929 |
AKR1C1 | CYP19A1 | ENSSSCP00000042336 | ENSSSCP00000046988 | Aldo-keto reductase family 1 member C3 isoform 2. | Aromatase 3; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Belongs to the cytochrome P450 family. | 0.934 |
AKR1C1 | HSD17B3 | ENSSSCP00000042336 | ENSSSCP00000011661 | Aldo-keto reductase family 1 member C3 isoform 2. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.929 |
AKR1C1 | HSD3B1 | ENSSSCP00000042336 | ENSSSCP00000007165 | Aldo-keto reductase family 1 member C3 isoform 2. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.939 |
AKR1C1 | LOC100525350 | ENSSSCP00000042336 | ENSSSCP00000019813 | Aldo-keto reductase family 1 member C3 isoform 2. | S5A_REDUCTASE domain-containing protein. | 0.931 |
AKR1C1 | LOC100622246 | ENSSSCP00000042336 | ENSSSCP00000044388 | Aldo-keto reductase family 1 member C3 isoform 2. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.939 |
AKR1C1 | SRD5A1 | ENSSSCP00000042336 | ENSSSCP00000018120 | Aldo-keto reductase family 1 member C3 isoform 2. | S5A_REDUCTASE domain-containing protein. | 0.943 |
AKR1C1 | SRD5A2 | ENSSSCP00000042336 | ENSSSCP00000009087 | Aldo-keto reductase family 1 member C3 isoform 2. | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). | 0.937 |
AKR1C1 | SULT1E1 | ENSSSCP00000042336 | ENSSSCP00000035891 | Aldo-keto reductase family 1 member C3 isoform 2. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.942 |
CBR1 | AKR1C1 | ENSSSCP00000052333 | ENSSSCP00000042336 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity). | Aldo-keto reductase family 1 member C3 isoform 2. | 0.943 |
CBR1 | LOC100622246 | ENSSSCP00000052333 | ENSSSCP00000044388 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity). | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.901 |
CYP17A1 | AKR1C1 | ENSSSCP00000011283 | ENSSSCP00000042336 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1 member C3 isoform 2. | 0.929 |
CYP17A1 | CYP19A1 | ENSSSCP00000011283 | ENSSSCP00000046988 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aromatase 3; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Belongs to the cytochrome P450 family. | 0.960 |
CYP17A1 | HSD17B3 | ENSSSCP00000011283 | ENSSSCP00000011661 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.992 |
CYP17A1 | HSD3B1 | ENSSSCP00000011283 | ENSSSCP00000007165 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.993 |
CYP17A1 | LOC100525350 | ENSSSCP00000011283 | ENSSSCP00000019813 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | S5A_REDUCTASE domain-containing protein. | 0.930 |
CYP17A1 | SRD5A1 | ENSSSCP00000011283 | ENSSSCP00000018120 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | S5A_REDUCTASE domain-containing protein. | 0.979 |
CYP17A1 | SRD5A2 | ENSSSCP00000011283 | ENSSSCP00000009087 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). | 0.967 |
CYP19A1 | AKR1C1 | ENSSSCP00000046988 | ENSSSCP00000042336 | Aromatase 3; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Belongs to the cytochrome P450 family. | Aldo-keto reductase family 1 member C3 isoform 2. | 0.934 |