STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC110255849G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (378 aa)    
Predicted Functional Partners:
EIF4E3
Eukaryotic translation initiation factor 4E family member 3; Belongs to the eukaryotic initiation factor 4E family.
      
 0.610
CH25H
Cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25- hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory eleme [...]
      
 0.575
HSD3B7
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7.
      
 0.518
CYP7B1
Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.
      
 0.478
PARM1
Uncharacterized protein.
    
 
 0.460
EIF4EBP1
Uncharacterized protein.
      
 0.452
RDH10
Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.435
PTHLH
Parathyroid hormone like hormone.
      
 0.407
ATP1B2
Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.
      
 0.406
RASGRP1
RAS guanyl releasing protein 1.
      
 0.404
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.