STOM protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

STOM

Stomatin. (267 aa)

Predicted Functional Partners:

PHB2

0.879

PHB

0.827

RHAG

0.808

FLOT2

0.777

FLOT1

0.763

FMNL2

0.680

BCS1L

0.651

SPG7

0.651

SRI

0.643

KCNQ4

0.624

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCS1L	PHB	ENSSSCP00000049876	ENSSSCP00000018597	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family.	Prohibitin.	0.651
BCS1L	PHB2	ENSSSCP00000049876	ENSSSCP00000026414	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family.	Prohibitin.	0.655
BCS1L	STOM	ENSSSCP00000049876	ENSSSCP00000050484	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family.	Stomatin.	0.651
FLOT1	FLOT2	ENSSSCP00000029813	ENSSSCP00000044809	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.959
FLOT1	FMNL2	ENSSSCP00000029813	ENSSSCP00000073266	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	Formin like 2.	0.405
FLOT1	PHB	ENSSSCP00000029813	ENSSSCP00000018597	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	Prohibitin.	0.461
FLOT1	PHB2	ENSSSCP00000029813	ENSSSCP00000026414	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	Prohibitin.	0.518
FLOT1	STOM	ENSSSCP00000029813	ENSSSCP00000050484	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	Stomatin.	0.763
FLOT2	FLOT1	ENSSSCP00000044809	ENSSSCP00000029813	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	0.959
FLOT2	FMNL2	ENSSSCP00000044809	ENSSSCP00000073266	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Formin like 2.	0.405
FLOT2	PHB	ENSSSCP00000044809	ENSSSCP00000018597	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Prohibitin.	0.461
FLOT2	PHB2	ENSSSCP00000044809	ENSSSCP00000026414	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Prohibitin.	0.513
FLOT2	STOM	ENSSSCP00000044809	ENSSSCP00000050484	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Stomatin.	0.777
FMNL2	FLOT1	ENSSSCP00000073266	ENSSSCP00000029813	Formin like 2.	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	0.405
FMNL2	FLOT2	ENSSSCP00000073266	ENSSSCP00000044809	Formin like 2.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.405
FMNL2	STOM	ENSSSCP00000073266	ENSSSCP00000050484	Formin like 2.	Stomatin.	0.680
KCNQ4	STOM	ENSSSCP00000004297	ENSSSCP00000050484	Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family.	Stomatin.	0.624
PHB	BCS1L	ENSSSCP00000018597	ENSSSCP00000049876	Prohibitin.	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family.	0.651
PHB	FLOT1	ENSSSCP00000018597	ENSSSCP00000029813	Prohibitin.	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	0.461
PHB	FLOT2	ENSSSCP00000018597	ENSSSCP00000044809	Prohibitin.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.461

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Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.917

expected number of edges:

13

PPI enrichment p-value:

0.000104

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007218

Neuropeptide signaling pathway

4 of 96

1.92

1.39

0.0017

GO:0007186

G protein-coupled receptor signaling pathway

8 of 1734

0.96

0.78

0.0017

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005184

Neuropeptide hormone activity

3 of 24

2.4

1.59

0.0011

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23404625

(2013) Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation.

4 of 10

2.9

2.58

1.96e-05

PMID:32673481

(2020) Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development.

4 of 14

2.75

2.46

3.00e-05

PMID:30413707

(2018) Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.

4 of 26

2.49

2.01

0.00018

PMID:22709252

(2012) Nonpeptide ligands of neuropeptide FF: current status and structural insights.

3 of 5

3.08

1.74

0.00072

PMID:22708927

(2012) Selective mode of action of guanidine-containing non-peptides at human NPFF receptors.

3 of 6

3.0

1.73

0.00075

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23904

Orexin and neuropeptides FF and QRFP bind to their respective receptors, and Negative regulation of gonadotropin secretion

3 of 6

3.0

2.59

1.91e-05

CL:23811

Neuropeptide signaling pathway, and Regulation of systemic arterial blood pressure by hormone

5 of 108

1.96

2.42

7.31e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

bta04080

Neuroactive ligand-receptor interaction

5 of 327

1.48

1.55

0.00011

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0027

Amidation

4 of 37

2.33

2.95

1.74e-06

KW-0527

Neuropeptide

3 of 16

2.57

2.49

2.28e-05

KW-0165

Cleavage on pair of basic residues

3 of 123

1.69

1.11

0.0050

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