ITGA2B protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ITGA2B

Uncharacterized protein. (1645 aa)

Predicted Functional Partners:

KMT2C

0.638

ITGA8

0.627

KRR1

0.625

ITGA2

0.589

ITGA5

0.584

ITGAV

0.579

ITGA9

0.554

ITGA3

0.554

ITGA6

0.554

ITGA7

0.554

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ITGA2	ITGA2B	ENSSSCP00000017895	ENSSSCP00000051602	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Uncharacterized protein.	0.589
ITGA2	ITGA3	ENSSSCP00000017895	ENSSSCP00000028475	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	0.782
ITGA2	ITGA5	ENSSSCP00000017895	ENSSSCP00000000308	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.768
ITGA2	ITGA6	ENSSSCP00000017895	ENSSSCP00000031111	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.865
ITGA2	ITGA7	ENSSSCP00000017895	ENSSSCP00000036625	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.734
ITGA2	ITGA8	ENSSSCP00000017895	ENSSSCP00000011782	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 8; Belongs to the integrin alpha chain family.	0.709
ITGA2	ITGA9	ENSSSCP00000017895	ENSSSCP00000011991	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 9; Belongs to the integrin alpha chain family.	0.660
ITGA2	ITGAV	ENSSSCP00000017895	ENSSSCP00000031102	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.776
ITGA2B	ITGA2	ENSSSCP00000051602	ENSSSCP00000017895	Uncharacterized protein.	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.589
ITGA2B	ITGA3	ENSSSCP00000051602	ENSSSCP00000028475	Uncharacterized protein.	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	0.554
ITGA2B	ITGA5	ENSSSCP00000051602	ENSSSCP00000000308	Uncharacterized protein.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.584
ITGA2B	ITGA6	ENSSSCP00000051602	ENSSSCP00000031111	Uncharacterized protein.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.554
ITGA2B	ITGA7	ENSSSCP00000051602	ENSSSCP00000036625	Uncharacterized protein.	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.554
ITGA2B	ITGA8	ENSSSCP00000051602	ENSSSCP00000011782	Uncharacterized protein.	Integrin subunit alpha 8; Belongs to the integrin alpha chain family.	0.627
ITGA2B	ITGA9	ENSSSCP00000051602	ENSSSCP00000011991	Uncharacterized protein.	Integrin subunit alpha 9; Belongs to the integrin alpha chain family.	0.554
ITGA2B	ITGAV	ENSSSCP00000051602	ENSSSCP00000031102	Uncharacterized protein.	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.579
ITGA2B	KMT2C	ENSSSCP00000051602	ENSSSCP00000040305	Uncharacterized protein.	Lysine methyltransferase 2C.	0.638
ITGA2B	KRR1	ENSSSCP00000051602	ENSSSCP00000054044	Uncharacterized protein.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.625
ITGA3	ITGA2	ENSSSCP00000028475	ENSSSCP00000017895	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.782
ITGA3	ITGA2B	ENSSSCP00000028475	ENSSSCP00000051602	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Uncharacterized protein.	0.554

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.948

expected number of edges:

47

PPI enrichment p-value:

0.53

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 229

1.81

3.04

2.77e-08

GO:0010467

Gene expression

9 of 1738

1.04

1.14

4.44e-06

GO:0022618

Ribonucleoprotein complex assembly

3 of 155

1.61

0.8

0.0239

GO:0000387

Spliceosomal snRNP assembly

2 of 30

2.15

0.75

0.0415

GO:0034641

Cellular nitrogen compound metabolic process

9 of 3050

0.79

0.67

0.00044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990935

Splicing factor binding

2 of 4

3.02

1.34

0.0038

GO:0003723

RNA binding

8 of 1208

1.14

1.24

2.24e-05

GO:0003676

Nucleic acid binding

9 of 3699

0.71

0.53

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005686

U2 snRNP

5 of 20

2.72

5.12

1.89e-10

GO:0071011

Precatalytic spliceosome

6 of 53

2.38

4.86

1.24e-10

GO:0005684

U2-type spliceosomal complex

6 of 92

2.14

4.22

5.76e-10

GO:0071005

U2-type precatalytic spliceosome

5 of 48

2.34

4.12

5.07e-09

GO:0005681

Spliceosomal complex

7 of 176

1.92

3.93

1.89e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18986

U2 snRNP, and Nuclear cap binding complex

6 of 23

2.74

5.91

5.02e-12

CL:18988

U2 snRNP

4 of 12

2.84

4.05

3.05e-08

CL:19002

Splicing factor binding, and PSP, proline-rich

3 of 5

3.1

3.14

1.97e-06

CL:19016

U4 snRNP

2 of 5

2.92

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

7 of 266

1.74

3.21

1.84e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72165

mRNA Splicing - Minor Pathway

6 of 59

2.33

4.64

2.98e-10

MAP-72172

mRNA Splicing

7 of 296

1.7

2.88

1.45e-08

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

7 of 391

1.57

2.48

5.54e-08

MAP-8953854

Metabolism of RNA

9 of 946

1.3

1.91

1.45e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

9 of 447

1.63

3.22

3.44e-11

GOCC:0097525

Spliceosomal snRNP complex

4 of 40

2.32

2.85

2.87e-06

GOCC:0005681

Spliceosomal complex

4 of 107

1.89

2.04

4.99e-05

GOCC:0005687

U4 snRNP

2 of 6

2.84

1.63

0.0011

GOCC:0005689

U12-type spliceosomal complex

2 of 8

2.72

1.53

0.0016

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0687

Ribonucleoprotein

4 of 93

1.96

2.16

3.14e-05

KW-0694

RNA-binding

4 of 347

1.38

1.06

0.0027

KW-0689

Ribosomal protein

2 of 63

1.82

0.7

0.0469

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