node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALAD | HMBS | ENSSSCP00000055833 | ENSSSCP00000053595 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase isoform 1. | 0.991 |
ALAD | UROD | ENSSSCP00000055833 | ENSSSCP00000004237 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.936 |
ALAD | UROS | ENSSSCP00000055833 | ENSSSCP00000049425 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen III synthase. | 0.994 |
GAPDH | HMBS | ENSSSCP00000035519 | ENSSSCP00000053595 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Porphobilinogen deaminase isoform 1. | 0.803 |
GAPDH | HPRT1 | ENSSSCP00000035519 | ENSSSCP00000041929 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.917 |
GAPDH | RPL4 | ENSSSCP00000035519 | ENSSSCP00000061269 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. | 0.711 |
GAPDH | SDHA | ENSSSCP00000035519 | ENSSSCP00000026945 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.802 |
GAPDH | TBP | ENSSSCP00000035519 | ENSSSCP00000040424 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Uncharacterized protein. | 0.902 |
GAPDH | YWHAZ | ENSSSCP00000035519 | ENSSSCP00000006472 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.864 |
HMBS | ALAD | ENSSSCP00000053595 | ENSSSCP00000055833 | Porphobilinogen deaminase isoform 1. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.991 |
HMBS | GAPDH | ENSSSCP00000053595 | ENSSSCP00000035519 | Porphobilinogen deaminase isoform 1. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.803 |
HMBS | HPRT1 | ENSSSCP00000053595 | ENSSSCP00000041929 | Porphobilinogen deaminase isoform 1. | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.859 |
HMBS | NFU1 | ENSSSCP00000053595 | ENSSSCP00000070176 | Porphobilinogen deaminase isoform 1. | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 2. | 0.807 |
HMBS | RPL4 | ENSSSCP00000053595 | ENSSSCP00000061269 | Porphobilinogen deaminase isoform 1. | 60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. | 0.814 |
HMBS | SDHA | ENSSSCP00000053595 | ENSSSCP00000026945 | Porphobilinogen deaminase isoform 1. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.875 |
HMBS | TBP | ENSSSCP00000053595 | ENSSSCP00000040424 | Porphobilinogen deaminase isoform 1. | Uncharacterized protein. | 0.867 |
HMBS | UROD | ENSSSCP00000053595 | ENSSSCP00000004237 | Porphobilinogen deaminase isoform 1. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.980 |
HMBS | UROS | ENSSSCP00000053595 | ENSSSCP00000049425 | Porphobilinogen deaminase isoform 1. | Uroporphyrinogen III synthase. | 0.993 |
HMBS | YWHAZ | ENSSSCP00000053595 | ENSSSCP00000006472 | Porphobilinogen deaminase isoform 1. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.838 |
HPRT1 | GAPDH | ENSSSCP00000041929 | ENSSSCP00000035519 | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.917 |