DIS3L2 protein (Sus scrofa) - STRING interaction network

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DIS3L2

DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (914 aa)

Predicted Functional Partners:

EXOSC10

0.974

EXOSC5

0.924

EXOSC4

0.924

EXOSC6

0.922

EXOSC3

0.920

EXOSC1

0.903

EXOSC8

0.898

EXOSC2

0.893

EXOSC7

0.884

EXOSC9

0.863

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DIS3L2	EXOSC1	ENSSSCP00000056716	ENSSSCP00000069176	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome component 1.	0.903
DIS3L2	EXOSC10	ENSSSCP00000056716	ENSSSCP00000003698	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome component 10.	0.974
DIS3L2	EXOSC2	ENSSSCP00000056716	ENSSSCP00000071461	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome component 2.	0.893
DIS3L2	EXOSC3	ENSSSCP00000056716	ENSSSCP00000005748	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome complex component RRP40 isoform 1.	0.920
DIS3L2	EXOSC4	ENSSSCP00000056716	ENSSSCP00000006334	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome complex component RRP41.	0.924
DIS3L2	EXOSC5	ENSSSCP00000056716	ENSSSCP00000003265	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome component 5.	0.924
DIS3L2	EXOSC6	ENSSSCP00000056716	ENSSSCP00000002934	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome component 6.	0.922
DIS3L2	EXOSC7	ENSSSCP00000056716	ENSSSCP00000012048	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Uncharacterized protein.	0.884
DIS3L2	EXOSC8	ENSSSCP00000056716	ENSSSCP00000060162	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome component 8.	0.898
DIS3L2	EXOSC9	ENSSSCP00000056716	ENSSSCP00000034219	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	Exosome component 9.	0.863
EXOSC1	DIS3L2	ENSSSCP00000069176	ENSSSCP00000056716	Exosome component 1.	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]	0.903
EXOSC1	EXOSC10	ENSSSCP00000069176	ENSSSCP00000003698	Exosome component 1.	Exosome component 10.	0.997
EXOSC1	EXOSC2	ENSSSCP00000069176	ENSSSCP00000071461	Exosome component 1.	Exosome component 2.	0.993
EXOSC1	EXOSC3	ENSSSCP00000069176	ENSSSCP00000005748	Exosome component 1.	Exosome complex component RRP40 isoform 1.	0.998
EXOSC1	EXOSC4	ENSSSCP00000069176	ENSSSCP00000006334	Exosome component 1.	Exosome complex component RRP41.	0.997
EXOSC1	EXOSC5	ENSSSCP00000069176	ENSSSCP00000003265	Exosome component 1.	Exosome component 5.	0.996
EXOSC1	EXOSC6	ENSSSCP00000069176	ENSSSCP00000002934	Exosome component 1.	Exosome component 6.	0.996
EXOSC1	EXOSC7	ENSSSCP00000069176	ENSSSCP00000012048	Exosome component 1.	Uncharacterized protein.	0.998
EXOSC1	EXOSC8	ENSSSCP00000069176	ENSSSCP00000060162	Exosome component 1.	Exosome component 8.	0.996
EXOSC1	EXOSC9	ENSSSCP00000069176	ENSSSCP00000034219	Exosome component 1.	Exosome component 9.	0.996

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