node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1QA | C1QB | ENSSSCP00000058150 | ENSSSCP00000063693 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Complement C1q B chain. | 0.998 |
C1QA | C1QC | ENSSSCP00000058150 | ENSSSCP00000034440 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Complement C1q subcomponent subunit C isoform 1. | 0.999 |
C1QA | C2 | ENSSSCP00000058150 | ENSSSCP00000001521 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.924 |
C1QA | C4A | ENSSSCP00000058150 | ENSSSCP00000061845 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Uncharacterized protein. | 0.936 |
C1QA | CALR | ENSSSCP00000058150 | ENSSSCP00000014615 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. | 0.912 |
C1QA | CSF1R | ENSSSCP00000058150 | ENSSSCP00000064716 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Colony stimulating factor 1 receptor. | 0.909 |
C1QA | SERPING1 | ENSSSCP00000058150 | ENSSSCP00000014011 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. | 0.971 |
C1QA | TREM2 | ENSSSCP00000058150 | ENSSSCP00000036723 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | Ig-like domain-containing protein. | 0.859 |
C1QA | TYROBP | ENSSSCP00000058150 | ENSSSCP00000003143 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.811 |
C1QA | VSIG4 | ENSSSCP00000058150 | ENSSSCP00000042591 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | V-set and immunoglobulin domain containing 4. | 0.898 |
C1QB | C1QA | ENSSSCP00000063693 | ENSSSCP00000058150 | Complement C1q B chain. | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | 0.998 |
C1QB | C1QC | ENSSSCP00000063693 | ENSSSCP00000034440 | Complement C1q B chain. | Complement C1q subcomponent subunit C isoform 1. | 0.998 |
C1QB | C2 | ENSSSCP00000063693 | ENSSSCP00000001521 | Complement C1q B chain. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.937 |
C1QB | C4A | ENSSSCP00000063693 | ENSSSCP00000061845 | Complement C1q B chain. | Uncharacterized protein. | 0.930 |
C1QB | CALR | ENSSSCP00000063693 | ENSSSCP00000014615 | Complement C1q B chain. | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. | 0.904 |
C1QB | CSF1R | ENSSSCP00000063693 | ENSSSCP00000064716 | Complement C1q B chain. | Colony stimulating factor 1 receptor. | 0.693 |
C1QB | SERPING1 | ENSSSCP00000063693 | ENSSSCP00000014011 | Complement C1q B chain. | Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. | 0.958 |
C1QB | TREM2 | ENSSSCP00000063693 | ENSSSCP00000036723 | Complement C1q B chain. | Ig-like domain-containing protein. | 0.420 |
C1QB | TYROBP | ENSSSCP00000063693 | ENSSSCP00000003143 | Complement C1q B chain. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.594 |
C1QC | C1QA | ENSSSCP00000034440 | ENSSSCP00000058150 | Complement C1q subcomponent subunit C isoform 1. | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | 0.999 |